{"id":"W2609912642","doi":"10.1159/000464443","title":"Synthetic, Switchable Enzymes","year":2017,"lang":"en","type":"review","venue":"Microbial Physiology","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":639,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Science and Technology Facilities Council; National Institutes of Health","keywords":"Aptamer; Substrate (aquarium); Linker; Combinatorial chemistry; Pairwise comparison; Biology; Enzyme; Biophysics; Biochemistry; Chemistry; Computer science; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000149543,0.0005294781,0.001514375,0.00009887611,0.0002307769,0.00004148866,0.0006917102,0.0008472282,0.00001055097],"category_scores_gemma":[0.00009734987,0.0004128027,0.0008475196,0.00005880261,0.000321463,0.000002620722,0.0004136013,0.0002747338,0.00007712541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002634872,"about_ca_system_score_gemma":0.0001649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001568373,"about_ca_topic_score_gemma":0.00001607141,"domain_scores_codex":[0.9979955,0.0001692772,0.0004283358,0.0009094709,0.00005924059,0.0004381916],"domain_scores_gemma":[0.9979389,0.00001884631,0.0005275178,0.001372575,0.00007253738,0.00006958574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002092574,0.00006871521,9.835767e-8,0.001340188,0.0003655386,0.000006410386,0.000001941242,1.823525e-7,0.254794,0.00003836553,0.01472462,0.728639],"study_design_scores_gemma":[0.00007365603,0.0001037752,3.513366e-7,0.0008948316,0.0003310389,0.00006425275,0.000001218664,2.031007e-7,0.03038933,0.00005248614,0.967622,0.0004668773],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004432219,0.998473,0.00005164941,0.00001672196,0.0002626531,0.0002951502,0.0001186354,0.00005323708,0.0006846031],"genre_scores_gemma":[0.0004347023,0.9935193,0.0007331167,0.00009192764,0.0009638381,0.00002841818,0.0009661575,0.00007468584,0.003187853],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9528974,"threshold_uncertainty_score":0.9998324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03969574473920007,"score_gpt":0.3476558525852039,"score_spread":0.3079601078460039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}