{"id":"W2609912642","doi":"10.1159/000464443","title":"Synthetic, Switchable Enzymes","year":2017,"lang":"en","type":"review","venue":"Microbial Physiology","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":639,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Science and Technology Facilities Council; National Institutes of Health","keywords":"Aptamer; Substrate (aquarium); Linker; Combinatorial chemistry; Pairwise comparison; Biology; Enzyme; Biophysics; Biochemistry; Chemistry; Computer science; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004242061,0.001027381,0.0007758393,0.001373517,0.0002103914,0.0009650233,0.0009666617,0.001105681,0.002557485],"category_scores_gemma":[0.0004454192,0.0004413476,0.0005298319,0.001426795,0.0005909728,0.001491138,0.0008049327,0.001833972,0.003572281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006521959,"about_ca_system_score_gemma":0.0003874802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003921502,"about_ca_topic_score_gemma":0.0005058491,"domain_scores_codex":[0.999679,0.00003697017,0.00003023688,0.00009953295,0.0001090026,0.0000452342],"domain_scores_gemma":[0.9999062,0.00002887385,0.00002197778,0.00001017397,0.00001920147,0.00001368271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008993992,0.0002034978,0.0002249132,0.01234839,0.00009578366,0.0005643998,0.0001525879,0.001996747,0.09767139,0.0472254,0.02124353,0.8181834],"study_design_scores_gemma":[0.00001999186,0.00009231703,0.000209026,0.0004714863,0.0000255112,0.0005916316,0.00002404752,0.0002482447,0.02865611,0.004113868,0.9655194,0.00002833982],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003899514,0.9623529,0.01116693,0.0004807663,0.001103883,0.00007207826,0.0002075954,0.0001770845,0.02053926],"genre_scores_gemma":[0.02921024,0.9405915,0.01182015,0.0007205958,0.0003369232,0.0001522453,0.0004883185,0.00004035522,0.01663968],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002557485,"threshold_uncertainty_score":0.008555651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03969574473920007,"score_gpt":0.3476558525852039,"score_spread":0.3079601078460039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}