{"id":"W2609921823","doi":"10.1186/s12868-017-0357-0","title":"Effects of escitalopram and paroxetine on mTORC1 signaling in the rat hippocampus under chronic restraint stress","year":2017,"lang":"en","type":"article","venue":"BMC Neuroscience","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Inje University","keywords":"Escitalopram; Paroxetine; PI3K/AKT/mTOR pathway; mTORC1; Antidepressant; Hippocampus; Chronic stress; Protein kinase B; Pharmacology; Endocrinology; Internal medicine; Psychology; Medicine; Signal transduction; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004310028,0.0002645999,0.0002392876,0.0001345483,0.0005406687,0.000380062,0.001747766,0.00005981032,0.00000547224],"category_scores_gemma":[0.001487373,0.0001951403,0.00006752506,0.0002805545,0.001469317,0.0004864648,0.0001744507,0.0004070398,0.000009504766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003239239,"about_ca_system_score_gemma":0.0001117865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002888002,"about_ca_topic_score_gemma":0.0000273,"domain_scores_codex":[0.997068,0.0004142507,0.000334607,0.0009049517,0.0007462532,0.0005319736],"domain_scores_gemma":[0.9977505,0.0008859208,0.0002888306,0.0009383185,0.00002052352,0.000115893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002817034,0.0001519168,0.008477337,0.00009716712,1.313112e-7,0.0001125213,0.0001659192,0.0004803211,0.9883294,0.0009524694,0.000005168135,0.001199479],"study_design_scores_gemma":[0.0006432398,0.0003941469,0.1450652,0.0001722334,0.000007790977,0.0000366554,0.00002300566,0.0002214675,0.8527973,0.0004039499,0.0000432905,0.0001917854],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979485,0.00002995547,0.0001074683,0.0003370756,0.0006422655,0.0007937214,0.000007954519,0.00003665604,0.00009638344],"genre_scores_gemma":[0.9987106,0.00004164119,0.00003329761,0.001035224,0.00005091689,0.00006770084,1.419842e-7,0.00002155562,0.00003892581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1365878,"threshold_uncertainty_score":0.7957592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04742707192820482,"score_gpt":0.3119439977855796,"score_spread":0.2645169258573747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}