{"id":"W2610037390","doi":"10.1021/acs.bioconjchem.7b00165","title":"Comparison of Tumor Penetration of Podophyllotoxin–Carboxymethylcellulose Conjugates with Various Chemical Compositions in Tumor Spheroid Culture and In Vivo Solid Tumor","year":2017,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of British Columbia","funders":"Canadian Institutes of Health Research; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; University of British Columbia","keywords":"In vivo; Chemistry; Conjugate; Podophyllotoxin; Penetration (warfare); Polyethylene glycol; Spheroid; PEG ratio; Biophysics; Drug delivery; Carboxymethyl cellulose; Nanoparticle; In vitro; Chromatography; Stereochemistry; Biochemistry; Nanotechnology; Organic chemistry; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002043707,0.0004046735,0.0002764095,0.0001845192,0.00007926848,0.0001918845,0.0001020292,0.0002283237,0.000426166],"category_scores_gemma":[0.0001922618,0.0001206844,0.0001881787,0.0001638623,0.0001249481,0.0002659145,0.0000888678,0.0003317995,0.0001310131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000264222,"about_ca_system_score_gemma":0.0001835378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008208163,"about_ca_topic_score_gemma":0.0008632133,"domain_scores_codex":[0.9998498,0.00003378345,0.00001811142,0.00003045091,0.00004475999,0.00002301662],"domain_scores_gemma":[0.9998191,0.00006186893,0.00004431291,0.00001773621,0.00002701073,0.00002995109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004107301,0.00002027688,0.0000938591,0.00001409237,0.000003984474,0.00001240818,0.00001373158,0.00008807842,0.9991071,0.00001424957,0.000005722882,0.0005855608],"study_design_scores_gemma":[0.000003860377,0.0003042751,0.001247138,0.000001179898,0.00001297053,0.00003096127,0.000007282131,0.0007690731,0.9973968,0.000005167519,0.0002198639,0.00000153937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951534,0.001019569,0.002816142,0.00003261508,0.00001486035,0.00002790509,0.0001102064,0.00003975694,0.0007854062],"genre_scores_gemma":[0.9933805,0.001074262,0.003592228,0.0000236834,0.000007022828,0.00004090596,0.0002741004,0.00002661134,0.001580621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008208163,"threshold_uncertainty_score":0.001917124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01756463661780572,"score_gpt":0.3249620958712126,"score_spread":0.3073974592534068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}