{"id":"W2610105836","doi":"10.1093/neuonc/nox036.006","title":"OS01.7 MGMT promoter methylation status independently predicts progression-free survival in NRG Oncology/RTOG 9802: a phase III trial of RT vs RT + PCV in high-risk low-grade gliomas","year":2017,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Oncology; Internal medicine; Medicine; Hazard ratio; Glioma; Progression-free survival; Methylation; Proportional hazards model; Oligodendroglioma; O-6-methylguanine-DNA methyltransferase; Biomarker; Statistical significance; Methyltransferase; Astrocytoma; Overall survival; Confidence interval; Biology; Cancer research; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001552227,0.0004858058,0.00173331,0.0008262221,0.0001866105,0.00004676389,0.0005345613,0.0008285104,0.000103032],"category_scores_gemma":[0.003054,0.0004032922,0.0002332748,0.0003966479,0.0003880844,0.0003048065,0.0004443859,0.0009818217,0.00002137504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008686603,"about_ca_system_score_gemma":0.001178158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001644872,"about_ca_topic_score_gemma":0.004717484,"domain_scores_codex":[0.9946491,0.001194336,0.001402857,0.0009699028,0.0008645856,0.000919276],"domain_scores_gemma":[0.9954811,0.00110387,0.001365143,0.00142258,0.0002167809,0.000410465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1430624,0.04104937,0.5198238,0.0001988968,0.0004650718,0.01040141,0.002430282,0.00003201196,0.09948647,0.0003204072,0.001329725,0.1814002],"study_design_scores_gemma":[0.6142374,0.03703262,0.2791385,0.0003092036,0.0006548672,0.0001252753,0.0001821987,0.0004481234,0.05787128,0.001122307,0.008440309,0.0004379344],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875388,0.0002013145,0.000009523542,0.003846988,0.002325214,0.004534581,0.0001329264,0.00007094922,0.00133975],"genre_scores_gemma":[0.9974478,0.0003416523,0.0004912755,0.0001681633,0.0004758228,0.0008611573,0.0001316125,0.00006778543,0.00001471498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4711749,"threshold_uncertainty_score":0.9998419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03174397573926484,"score_gpt":0.359153957720616,"score_spread":0.3274099819813511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}