{"id":"W2610105836","doi":"10.1093/neuonc/nox036.006","title":"OS01.7 MGMT promoter methylation status independently predicts progression-free survival in NRG Oncology/RTOG 9802: a phase III trial of RT vs RT + PCV in high-risk low-grade gliomas","year":2017,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Oncology; Internal medicine; Medicine; Hazard ratio; Glioma; Progression-free survival; Methylation; Proportional hazards model; Oligodendroglioma; O-6-methylguanine-DNA methyltransferase; Biomarker; Statistical significance; Methyltransferase; Astrocytoma; Overall survival; Confidence interval; Biology; Cancer research; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002043007,0.0006966604,0.0008187851,0.0001986873,0.0001779373,0.000543125,0.0004890076,0.0005383922,0.00227204],"category_scores_gemma":[0.001173163,0.000278241,0.0007608381,0.0002408042,0.0004202756,0.0003131874,0.000216555,0.001158866,0.000430987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005158962,"about_ca_system_score_gemma":0.0009037296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005814772,"about_ca_topic_score_gemma":0.001941925,"domain_scores_codex":[0.9994974,0.0003281863,0.00002509382,0.00006559002,0.00004309239,0.00004050255],"domain_scores_gemma":[0.99924,0.0001690596,0.0002647903,0.00007055813,0.00003925189,0.000216291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.811728,0.01571385,0.07480315,0.0003955229,0.001082467,0.00007715305,0.0001645414,0.002421866,0.02210462,0.0001118981,0.002020144,0.06937692],"study_design_scores_gemma":[0.2956947,0.5414925,0.1431151,0.00006178307,0.001814084,0.0004107858,0.00007814157,0.006074185,0.007744324,0.0003169757,0.003157562,0.00003992912],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985861,0.00037859,0.0001220527,0.0001101207,0.00001724802,0.0001928183,0.000247896,0.00001832274,0.0003269011],"genre_scores_gemma":[0.9970871,0.0002545281,0.0005757533,0.000169154,0.00004642871,0.0003302467,0.0007245057,0.00001245057,0.0007998347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00227204,"threshold_uncertainty_score":0.01080459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03174397573926484,"score_gpt":0.359153957720616,"score_spread":0.3274099819813511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}