{"id":"W2610213115","doi":"10.1172/jci91038","title":"Endocannabinoid signaling in hypothalamic circuits regulates arousal from general anesthesia in mice","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institute on Drug Abuse; National Institutes of Health; National Natural Science Foundation of China; Fourth Military Medical University; University of Ottawa; Canadian Institutes of Health Research; JPB Foundation","keywords":"Glutamatergic; Endocannabinoid system; Neuroscience; GABAergic; Excitatory postsynaptic potential; Lateral hypothalamus; Preoptic area; Arousal; Hypothalamus; Inhibitory postsynaptic potential; Glutamate receptor; Endocrinology; Chemistry; Internal medicine; Medicine; Psychology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.002374295,0.0001329974,0.0004617823,0.0002346419,0.0001273727,0.000208986,0.0007325796,0.0001827462,0.00002157574],"category_scores_gemma":[0.01178911,0.0001167015,0.0001354607,0.0001705253,0.0004255348,0.0008167546,0.0000541219,0.00086508,0.00001630699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006108375,"about_ca_system_score_gemma":0.0002830669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002403057,"about_ca_topic_score_gemma":0.00006189195,"domain_scores_codex":[0.996515,0.0007941732,0.001498784,0.0003113769,0.0005874888,0.0002932184],"domain_scores_gemma":[0.9969148,0.001315607,0.001150792,0.0002930573,0.0001105572,0.0002151828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001044745,0.0001473475,0.5197693,0.000009212614,0.000006552283,0.0010067,0.0002052406,0.0008200358,0.4655107,0.0003208425,0.00008873138,0.01201097],"study_design_scores_gemma":[0.00155806,0.0001268841,0.6286415,0.0001664924,0.000008216613,0.00008728966,0.0000221663,0.003134371,0.344851,0.0212327,0.0000529166,0.0001183453],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996219,0.00005186147,0.00002118445,0.003104785,0.000347368,0.0001220635,0.000001657321,0.000007299677,0.0001247633],"genre_scores_gemma":[0.9982628,0.00005937681,0.0003603861,0.0005459964,0.0006868451,0.000003985622,0.000001214485,0.00001646393,0.00006290359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1206596,"threshold_uncertainty_score":0.996535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1619572609209045,"score_gpt":0.395389904267725,"score_spread":0.2334326433468205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}