{"id":"W2610243507","doi":"10.3390/ijms18050928","title":"Significance of Wild-Type p53 Signaling in Suppressing Apoptosis in Response to Chemical Genotoxic Agents: Impact on Chemotherapy Outcome","year":2017,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"DNA damage; Biology; DNA repair; Cell cycle; Cell cycle checkpoint; Senescence; Apoptosis; Genome instability; Cell biology; Cancer research; Effector; Cell growth; Population; Genetics; DNA; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004075527,0.0005660162,0.0008344122,0.001572971,0.0002026551,0.0007866421,0.0006479702,0.0008041591,0.001662134],"category_scores_gemma":[0.0004705698,0.0001694479,0.0003197451,0.001038669,0.0004974709,0.0008226814,0.0004477486,0.001224366,0.0009879628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004859542,"about_ca_system_score_gemma":0.0006286025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004966751,"about_ca_topic_score_gemma":0.0009450152,"domain_scores_codex":[0.9998722,0.00002149112,0.00002256684,0.00002882797,0.0000422384,0.00001269821],"domain_scores_gemma":[0.9997965,0.0000917728,0.00002922287,0.000007549093,0.0000572144,0.00001783068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008408561,0.00006772105,0.0002820481,0.01078962,0.00007264286,0.000224187,0.00005819393,0.000313136,0.004700455,0.004558405,0.01164995,0.9671996],"study_design_scores_gemma":[0.00002008077,0.0002225404,0.00195619,0.002832068,0.0001444269,0.002723714,0.00006847536,0.0001580626,0.002859753,0.002804263,0.9861827,0.00002768803],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002402973,0.9983494,0.000137604,0.0001890177,0.0001024771,0.000004027259,0.00001241747,0.000006608431,0.0009580858],"genre_scores_gemma":[0.001527555,0.9976064,0.0001857065,0.0001199948,0.0001027295,0.00000692754,0.00001865332,0.00000145805,0.0004306617],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001662134,"threshold_uncertainty_score":0.005560398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09771342686643017,"score_gpt":0.4422420471264578,"score_spread":0.3445286202600276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}