{"id":"W2610439628","doi":"10.1101/133074","title":"Distinct features of multivesicular body-lysosome fusion revealed by a new cell-free content-mixing assay","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital; Concordia University","funders":"Natural Sciences and Engineering Research Council of Canada; Concordia University","keywords":"Lysosome; Endosome; Cell biology; Rab; Lipid bilayer fusion; Endocytosis; ESCRT; Fusion mechanism; Autophagy; Biology; Chemistry; GTPase; Cell; Biochemistry; Intracellular; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000727033,0.0009191297,0.0005375522,0.001671931,0.0003064151,0.0007500355,0.0007111063,0.0009226917,0.001095466],"category_scores_gemma":[0.0004650266,0.0004083149,0.000826577,0.000565314,0.0003863767,0.0004819083,0.0008131442,0.001140854,0.0008217217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003776223,"about_ca_system_score_gemma":0.0001775034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004566871,"about_ca_topic_score_gemma":0.0004118836,"domain_scores_codex":[0.9990714,0.0002627156,0.0001335175,0.0001504784,0.0002703454,0.0001115563],"domain_scores_gemma":[0.9990441,0.0002641737,0.0002698795,0.0001489933,0.0001289087,0.0001440106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004794069,0.00003500933,0.0002015003,0.00001995457,0.00001464478,0.0000248925,0.00002436695,0.00002457173,0.9988557,0.00009962668,0.00001500499,0.0006366826],"study_design_scores_gemma":[0.000005991716,0.0001437566,0.003431194,0.00000470708,0.00003490938,0.0001788089,0.0000161733,0.001485647,0.9939838,0.00006403511,0.0006354504,0.00001550599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9078651,0.002729823,0.08166793,0.0002456531,0.00009458595,0.000274401,0.001808778,0.0009119825,0.00440178],"genre_scores_gemma":[0.9442264,0.0008266829,0.04549838,0.00009947275,0.00002626331,0.0002664406,0.003058765,0.0001617691,0.005835901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001671931,"threshold_uncertainty_score":0.003844917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01200143534197294,"score_gpt":0.2108990077284017,"score_spread":0.1988975723864288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}