{"id":"W2610461060","doi":"10.1111/tra.12480","title":"Importin β1 targeting by hepatitis C virus <scp>NS3</scp>/<scp>4A</scp> protein restricts <scp>IRF3</scp> and <scp>NF‐κB</scp> signaling of <scp>IFNB1</scp> antiviral response","year":2017,"lang":"en","type":"article","venue":"Traffic","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Canadian Liver Foundation; Novartis","keywords":"IRF3; Nuclear transport; NS3; Biology; Cell biology; Nuclear export signal; Signal transducing adaptor protein; Innate immune system; Karyopherin; Importin; TLR3; Nuclear protein; Gene silencing; Transcription factor; Signal transduction; Cell nucleus; Virus; Virology; Hepatitis C virus; Immune system; Toll-like receptor; Cytoplasm; Biochemistry; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","sts","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity"],"category_scores_codex":[0.005263564,0.002279388,0.003058385,0.001414026,0.002776535,0.0007446003,0.002841986,0.002468972,0.00005217012],"category_scores_gemma":[0.03504268,0.002292526,0.001088057,0.0009579413,0.002603819,0.001343073,0.001295255,0.003140113,0.001140318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003250455,"about_ca_system_score_gemma":0.0009653294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001089503,"about_ca_topic_score_gemma":0.0002297994,"domain_scores_codex":[0.9851007,0.003728413,0.003504443,0.0027346,0.0007691924,0.004162604],"domain_scores_gemma":[0.9807377,0.01153837,0.003743979,0.002678277,0.0007679543,0.000533714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002338779,0.0009938845,0.00551366,0.0003734129,0.0009860861,0.0003482073,0.008034037,0.00007659671,0.8934325,0.0001721052,0.08772819,0.002107444],"study_design_scores_gemma":[0.005268548,0.002611893,0.01899257,0.000813282,0.0003882887,0.0003263645,0.006142406,0.0001643888,0.7888565,0.0000783167,0.1761358,0.0002216008],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9670959,0.02285704,0.0001482682,0.0001216344,0.002024501,0.002628097,0.000800805,0.0008266718,0.003497077],"genre_scores_gemma":[0.9561775,0.002630311,0.0005120958,0.0003103665,0.0004042273,0.0003147762,0.0005666139,0.0004449377,0.03863914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.104576,"threshold_uncertainty_score":0.9996374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01227338504708678,"score_gpt":0.2435516435347298,"score_spread":0.2312782584876431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}