{"id":"W2610461060","doi":"10.1111/tra.12480","title":"Importin β1 targeting by hepatitis C virus <scp>NS3</scp>/<scp>4A</scp> protein restricts <scp>IRF3</scp> and <scp>NF‐κB</scp> signaling of <scp>IFNB1</scp> antiviral response","year":2017,"lang":"en","type":"article","venue":"Traffic","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Canadian Liver Foundation; Novartis","keywords":"IRF3; Nuclear transport; NS3; Biology; Cell biology; Nuclear export signal; Signal transducing adaptor protein; Innate immune system; Karyopherin; Importin; TLR3; Nuclear protein; Gene silencing; Transcription factor; Signal transduction; Cell nucleus; Virus; Virology; Hepatitis C virus; Immune system; Toll-like receptor; Cytoplasm; Biochemistry; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000886835,0.0003273736,0.0001836199,0.000115685,0.0001968544,0.0002982867,0.0001218628,0.0002190323,0.0009090872],"category_scores_gemma":[0.00006240304,0.0001287851,0.0002949622,0.00009376924,0.0002474975,0.0001763593,0.0001684283,0.0004373995,0.0003863557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003565054,"about_ca_system_score_gemma":0.0002015801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008626715,"about_ca_topic_score_gemma":0.001225193,"domain_scores_codex":[0.9999158,0.00000924952,0.000007656911,0.00002106152,0.0000255089,0.00002067552],"domain_scores_gemma":[0.9999304,0.000008855895,0.00002551224,0.000009971861,0.000009503327,0.00001568939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003673292,0.000004319229,0.00006479076,0.00001211715,0.000002120323,0.00001496121,0.000004297334,0.00002073622,0.9996269,0.00002021994,0.000008393615,0.0001844249],"study_design_scores_gemma":[0.000003517335,0.00004558536,0.001582647,0.000001832731,0.000004894017,0.0001169018,0.0000104636,0.0004594628,0.99701,0.0000189486,0.0007436845,0.000002015481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947894,0.0008131744,0.003122312,0.00006832751,0.00001431567,0.00001746991,0.0002653479,0.00007667037,0.000832968],"genre_scores_gemma":[0.994458,0.0004771886,0.002549042,0.00004314538,0.000003566602,0.00001934404,0.0004820585,0.00003663126,0.001931119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009090872,"threshold_uncertainty_score":0.003041208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01227338504708678,"score_gpt":0.2435516435347298,"score_spread":0.2312782584876431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}