{"id":"W2610482090","doi":"10.1097/aln.0000000000001665","title":"High Concentrations of Tranexamic Acid Inhibit Ionotropic Glutamate Receptors","year":2017,"lang":"en","type":"article","venue":"Anesthesiology","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"Canadian Institutes of Health Research","keywords":"Kainate receptor; Tranexamic acid; Ionotropic effect; NMDA receptor; Receptor; 2-Amino-5-phosphonovalerate; Agonist; AMPA receptor; Pharmacology; Glycine receptor; Long-term depression; Glutamate receptor; Glycine; Medicine; Biochemistry; Chemistry; Internal medicine; Amino acid; Excitatory Amino Acid Antagonists","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001753517,0.0005428748,0.0004672851,0.0002264234,0.0001557287,0.0004217737,0.000295888,0.0003678432,0.003326612],"category_scores_gemma":[0.0004703272,0.000147207,0.0002846875,0.000205582,0.0001976718,0.0002685637,0.0002659854,0.0006754732,0.000650209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003498551,"about_ca_system_score_gemma":0.0002346919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001023921,"about_ca_topic_score_gemma":0.001330813,"domain_scores_codex":[0.9996052,0.00007504954,0.0000617929,0.00004811046,0.000131169,0.00007852218],"domain_scores_gemma":[0.9996922,0.00007248692,0.00008752293,0.00003391828,0.00005603743,0.00005791741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002776209,0.00002763473,0.0002379739,0.0001014291,0.00002645322,0.00009160547,0.00001501347,0.00006262687,0.9966639,0.00008986057,0.0000691092,0.002336647],"study_design_scores_gemma":[0.0000473557,0.001260207,0.003984677,0.00002642555,0.00004458311,0.0006541266,0.00003841685,0.0004539842,0.9899199,0.00006053572,0.003503497,0.00000630032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9755552,0.01407443,0.004100586,0.0002400132,0.0001337144,0.00008268563,0.000553792,0.0001077724,0.00515181],"genre_scores_gemma":[0.9917389,0.003693594,0.002512342,0.000121771,0.00005215978,0.00006076356,0.0003923911,0.00001218933,0.001415826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003326612,"threshold_uncertainty_score":0.01112866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05794818372086886,"score_gpt":0.3313092049760994,"score_spread":0.2733610212552305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}