{"id":"W2610629385","doi":"10.1177/1010428317699115","title":"Novel candidate genes may be possible predisposing factors revealed by whole exome sequencing in familial esophageal squamous cell carcinoma","year":2017,"lang":"en","type":"article","venue":"Tumor Biology","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; BC Cancer Agency","funders":"","keywords":"Candidate gene; Exome sequencing; Biology; Exome; Genetics; Gene; Proband; Notch signaling pathway; Mutation; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002245282,0.0002911609,0.0005310168,0.0001648732,0.0003204724,0.00005052523,0.0003035266,0.0001281032,0.00007474947],"category_scores_gemma":[0.0001094427,0.000229965,0.00010017,0.00008757428,0.0002734476,0.0001196801,0.0001608281,0.0003224837,0.00002236684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007211828,"about_ca_system_score_gemma":0.0005335147,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0169554,"about_ca_topic_score_gemma":0.001021164,"domain_scores_codex":[0.9980337,0.00008073854,0.0003386565,0.0005598132,0.0001921476,0.0007949493],"domain_scores_gemma":[0.9987471,0.00007895155,0.0001731498,0.0006228367,0.00006070594,0.0003172388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003732986,0.0001384356,0.8312161,0.0001049699,0.00001828561,0.0009364327,0.0002733517,0.000003827778,0.1663253,0.00001929807,0.0001897859,0.000400889],"study_design_scores_gemma":[0.007434568,0.001910302,0.8543322,0.00004147244,0.0000598233,0.000143182,0.0002185183,0.0001717564,0.1351458,0.00004737264,0.0002308465,0.0002640907],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920369,0.005243215,0.00001817651,0.0004227184,0.0002278109,0.0006194413,0.0005659957,0.00004335153,0.0008224157],"genre_scores_gemma":[0.99733,0.00003982466,0.000214244,0.0001778311,0.0001926572,0.00005884935,0.0003637686,0.00003657405,0.001586303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03117951,"threshold_uncertainty_score":0.9895908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03627188326787239,"score_gpt":0.3163655434318912,"score_spread":0.2800936601640188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}