{"id":"W2610629385","doi":"10.1177/1010428317699115","title":"Novel candidate genes may be possible predisposing factors revealed by whole exome sequencing in familial esophageal squamous cell carcinoma","year":2017,"lang":"en","type":"article","venue":"Tumor Biology","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; BC Cancer Agency","funders":"","keywords":"Candidate gene; Exome sequencing; Biology; Exome; Genetics; Gene; Proband; Notch signaling pathway; Mutation; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002537743,0.0003965718,0.0003725232,0.0008222364,0.0002783309,0.0002406213,0.0001619769,0.0003845172,0.001307957],"category_scores_gemma":[0.0007588754,0.0001210157,0.0003629124,0.0006289509,0.0001822588,0.0001341757,0.0001797135,0.0002052608,0.0001433333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001142058,"about_ca_system_score_gemma":0.0001229065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007660613,"about_ca_topic_score_gemma":0.001413561,"domain_scores_codex":[0.999831,0.00002861347,0.00002533906,0.00005589927,0.00003782146,0.00002135725],"domain_scores_gemma":[0.9997666,0.0001094637,0.0000572645,0.0000173912,0.00002115302,0.00002817965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001251738,0.0001518881,0.598976,0.0001992483,0.0005148672,0.05537649,0.0008434043,0.00330696,0.3070434,0.0004995302,0.0005225349,0.03131394],"study_design_scores_gemma":[0.00003814515,0.0002179191,0.9134234,0.00004515998,0.0005089986,0.04600475,0.0004052761,0.00742899,0.029148,0.0007386137,0.002007723,0.00003308288],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978916,0.0002435448,0.001496785,0.0000295834,0.000003974298,0.000008589495,0.0001600137,0.00001391098,0.0001519891],"genre_scores_gemma":[0.9979195,0.0001552299,0.001440573,0.00003385959,0.000005134279,0.000005953506,0.0002404372,0.000006341204,0.0001929897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001307957,"threshold_uncertainty_score":0.004375577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03627188326787239,"score_gpt":0.3163655434318912,"score_spread":0.2800936601640188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}