{"id":"W2610703040","doi":"10.1007/s00401-017-1715-9","title":"Meningiomas induced by low-dose radiation carry structural variants of NF2 and a distinct mutational signature","year":2017,"lang":"en","type":"letter","venue":"Acta Neuropathologica","topic":"Meningioma and schwannoma management","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre","funders":"Deutsche Krebshilfe; Else Kröner-Fresenius-Stiftung","keywords":"Signature (topology); Genetics; Carry (investment); Biology; Computational biology; Medicine; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000246921,0.0004530399,0.0003867795,0.0003829616,0.0006866179,0.0008377946,0.0004359592,0.002604777,0.001506131],"category_scores_gemma":[0.002127994,0.0001771742,0.0004105447,0.0004588005,0.0009158394,0.0006187328,0.0003754649,0.001627396,0.0005454437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008055745,"about_ca_system_score_gemma":0.0003485886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008991409,"about_ca_topic_score_gemma":0.001330444,"domain_scores_codex":[0.9997649,0.00003725331,0.00002982619,0.00004209758,0.00005376133,0.0000722336],"domain_scores_gemma":[0.9993834,0.0002520424,0.0001263546,0.00007428954,0.00006924493,0.00009461989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003024514,0.00004193046,0.04158688,0.00008979163,0.00003384694,0.9239436,0.0002875188,0.0002273474,0.02002562,0.001291874,0.003597937,0.00857114],"study_design_scores_gemma":[0.0000328013,0.00007629477,0.02114329,0.00003542795,0.00004229719,0.9654246,0.000308082,0.0006004804,0.003820107,0.001874088,0.006626247,0.000016256],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"editorial","genre_scores_codex":[0.9417186,0.003741786,0.002391937,0.02541708,0.001036533,0.00004799453,0.0002505142,0.0001804018,0.02521524],"genre_scores_gemma":[0.9948915,0.0006816625,0.0006993389,0.00185872,0.0007375862,0.000008066497,0.00006031697,0.00001891731,0.001043895],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.002604777,"threshold_uncertainty_score":0.005844831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02154907225288667,"score_gpt":0.2664090469474228,"score_spread":0.2448599746945361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}