{"id":"W2610732323","doi":"10.1002/cncy.21868","title":"Consistency and reproducibility of next‐generation sequencing and other multigene mutational assays: A worldwide ring trial study on quantitative cytological molecular reference specimens","year":2017,"lang":"en","type":"article","venue":"Cancer Cytopathology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"Public Health Agency","keywords":"Medicine; Reproducibility; Computational biology; Consistency (knowledge bases); DNA sequencing; Medical physics; Molecular diagnostics; Bioinformatics; Oncology; Genetics; Biology; DNA; Chromatography; Artificial intelligence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005165991,0.0001363984,0.0003723027,0.00006636053,0.0002165756,0.00002680203,0.00005226514,0.00006730703,0.00002942614],"category_scores_gemma":[0.0009334816,0.0001089227,0.00003275817,0.00003904826,0.0003162521,0.00007355789,0.00004561537,0.0001230019,0.000001232531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001409385,"about_ca_system_score_gemma":0.0002076087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004151281,"about_ca_topic_score_gemma":0.0003736388,"domain_scores_codex":[0.9984969,0.0001591017,0.0003060019,0.0007654048,0.0001347883,0.0001377416],"domain_scores_gemma":[0.9987662,0.0001003973,0.000252291,0.0006629627,0.0001537733,0.00006432083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.009321061,0.001048161,0.4266561,0.00008717935,0.0004297431,0.0007203282,0.008137329,0.0001260065,0.5309732,0.01430992,0.00001890399,0.00817207],"study_design_scores_gemma":[0.03104699,0.005183021,0.9413658,0.0001184015,0.0005911963,0.0001173337,0.002156065,0.0004925454,0.01777742,0.000835242,0.00007903449,0.0002369378],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961643,0.0006693025,0.0001771181,0.0004127118,0.0002211388,0.001015798,0.00004611024,0.00001511884,0.001278409],"genre_scores_gemma":[0.9976708,0.00003078635,0.001734972,0.0001903901,0.00008918064,0.0001751048,0.00001104291,0.00001075263,0.00008700754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5147097,"threshold_uncertainty_score":0.444174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2648634268306701,"score_gpt":0.4402387328564022,"score_spread":0.1753753060257321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}