{"id":"W2610755628","doi":"10.1155/2017/2380531","title":"New Caffeic Acid Phenylethyl Ester Analogs Bearing Substituted Triazole: Synthesis and Structure-Activity Relationship Study towards 5-Lipoxygenase Inhibition","year":2017,"lang":"en","type":"article","venue":"Journal of Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Moncton","funders":"Natural Sciences and Engineering Research Council of Canada; New Brunswick Innovation Foundation; Université de Moncton","keywords":"Chemistry; Zileuton; Arachidonate 5-lipoxygenase; Stereochemistry; Caffeic acid phenethyl ester; Moiety; Triazole; Docking (animal); Caffeic acid; Cycloaddition; Druggability; Enzyme; Arachidonic acid; Combinatorial chemistry; Biochemistry; Organic chemistry; Catalysis; Antioxidant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000486564,0.0002633155,0.0005237842,0.000033816,0.0003845521,0.0002653498,0.0003167971,0.000299554,0.0006885129],"category_scores_gemma":[0.002589546,0.0001990809,0.0001766221,0.00005269781,0.00011435,0.0004673088,0.000133746,0.0006408765,0.000001629791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001255634,"about_ca_system_score_gemma":0.0001484205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001073747,"about_ca_topic_score_gemma":0.00002077429,"domain_scores_codex":[0.9985731,0.00005014773,0.0004507262,0.0002973672,0.0003705984,0.0002580892],"domain_scores_gemma":[0.9978356,0.0002882922,0.001013156,0.0004634571,0.0001178096,0.0002816975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003161137,0.0002125948,0.05477277,0.00008149746,0.0001224619,0.00007875232,0.00007827263,0.000002432019,0.9181503,0.000001268241,0.00006713305,0.02611638],"study_design_scores_gemma":[0.0009419741,0.00001995965,0.1908592,0.0001031685,0.0001488306,0.0001228258,0.0001250655,0.00001066608,0.8071903,0.0002030649,0.00007835831,0.0001966061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977456,0.0001556517,0.00009140866,0.0003544865,0.00008111288,0.00005646175,0.0000282148,0.00002101567,0.00146606],"genre_scores_gemma":[0.9988317,0.00002368808,0.00030533,0.000008666252,0.0006834024,0.000002966349,0.000002543555,0.00001574596,0.0001259051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1360864,"threshold_uncertainty_score":0.8118284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03999520942188462,"score_gpt":0.2781785367228046,"score_spread":0.23818332730092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}