{"id":"W2610797094","doi":"10.1016/j.jmb.2017.04.016","title":"An in vitro Model to Mimic Selection of Replication-Competent HIV-1 Intersubtype Recombination in Dual or Superinfected Patients","year":2017,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Biology; Recombination; Virology; Genetics; Selection (genetic algorithm); Virus; Recombinant DNA; Breakpoint; Viral replication; Human immunodeficiency virus (HIV); Homologous recombination; DNA; Gene; Chromosomal translocation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005651171,0.0004441836,0.000454508,0.0002811168,0.0004212969,0.0007730766,0.0006283562,0.0006613192,0.003041341],"category_scores_gemma":[0.000411615,0.0002659421,0.0004244899,0.0002504541,0.0002643933,0.0002284256,0.0003656376,0.001492216,0.001060924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004552324,"about_ca_system_score_gemma":0.0003630607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009258077,"about_ca_topic_score_gemma":0.001281431,"domain_scores_codex":[0.9990897,0.0004479159,0.0000599725,0.0001485749,0.0001322933,0.0001214645],"domain_scores_gemma":[0.9995254,0.0001697055,0.00006911542,0.0001270902,0.00003697055,0.00007172631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008022283,0.0005814832,0.000902093,0.0001031976,0.00001851006,0.0005799052,0.0001594484,0.001029708,0.9920589,0.001612736,0.0004379035,0.001713852],"study_design_scores_gemma":[0.0001169279,0.003837119,0.002389915,0.00003238049,0.00007994105,0.002733814,0.0001895852,0.005927771,0.9756668,0.0004163696,0.008578835,0.00003072938],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9698786,0.001630639,0.01996798,0.0003384969,0.0003293019,0.0004037408,0.001887441,0.0001654655,0.005398498],"genre_scores_gemma":[0.9800142,0.000868499,0.01399801,0.0002445575,0.0000548454,0.0003935643,0.001302939,0.00005333602,0.003070088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003041341,"threshold_uncertainty_score":0.01017427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01865095263867561,"score_gpt":0.3190814212736025,"score_spread":0.3004304686349268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}