{"id":"W2610814011","doi":"10.1016/s0140-6736(17)31191-1","title":"Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a 1-year, randomised, double-blinded, placebo-controlled, phase 3 trial","year":2017,"lang":"en","type":"article","venue":"The Lancet","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":1243,"is_retracted":false,"has_abstract":false,"ca_institutions":"Probity Medical Research; University of British Columbia; Queen's University","funders":"British Association of Dermatologists","keywords":"Dupilumab; Eczema Area and Severity Index; Atopic dermatitis; Medicine; Placebo; Concomitant; Clinical endpoint; Dermatology; Dermatology Life Quality Index; Internal medicine; Randomized controlled trial; Placebo-controlled study; Disease; Double blind; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002053037,0.001651673,0.003895798,0.0003562835,0.0005878712,0.00119672,0.001161797,0.002870704,0.005091029],"category_scores_gemma":[0.001511981,0.000624373,0.003145536,0.0003418182,0.001351932,0.001260769,0.0004113839,0.004271226,0.0009384074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008327775,"about_ca_system_score_gemma":0.0009186964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001214323,"about_ca_topic_score_gemma":0.003225104,"domain_scores_codex":[0.9993854,0.000246447,0.00004438087,0.0001274771,0.00005864804,0.0001375934],"domain_scores_gemma":[0.9991395,0.0002701172,0.0001596829,0.00005915393,0.00004788385,0.0003235341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9747542,0.003599157,0.0005167909,0.001263755,0.001301744,0.00005890503,0.00006055076,0.0001665221,0.001794328,0.0000927601,0.0008141979,0.01557706],"study_design_scores_gemma":[0.9565667,0.0406829,0.001387934,0.00005562049,0.0004501824,0.00004598818,0.00002015402,0.000129214,0.0001487165,0.00006819473,0.0004326333,0.00001176767],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9661481,0.02495288,0.0007859406,0.0010607,0.00129078,0.002219903,0.0009115093,0.0001669776,0.002463246],"genre_scores_gemma":[0.9807658,0.008135932,0.001435746,0.002008241,0.0008683108,0.00245016,0.001108991,0.00002483981,0.003202074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005091029,"threshold_uncertainty_score":0.01703125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03563158057817713,"score_gpt":0.3192870028795328,"score_spread":0.2836554223013557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}