{"id":"W2610818384","doi":"10.1093/jac/dkx118","title":"HIV-1 strains belonging to large phylogenetic clusters show accelerated escape from integrase inhibitors in cell culture compared with viral isolates from singleton/small clusters","year":2017,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Centre Hospitalier de l’Université de Montréal; McGill University; Jewish General Hospital","funders":"Center for AIDS Research, University of Washington; National Institute of Allergy and Infectious Diseases; Fonds de recherche du Québec; Vlaamse regering; Canadian Institutes of Health Research; Genome Canada; Fonds Wetenschappelijk Onderzoek; McGill University; National Institutes of Health; Case Western Reserve University; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Dolutegravir; Elvitegravir; Biology; Virology; Phylogenetic tree; Integrase; Genetics; Viral evolution; Cluster (spacecraft); Integrase inhibitor; Viral load; Human immunodeficiency virus (HIV); Genome; Gene; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002480266,0.0002083256,0.0001864066,0.0004035721,0.0007636957,0.0005696016,0.0002366946,0.0002644168,0.002772715],"category_scores_gemma":[0.0004775615,0.0001409194,0.000179472,0.0005564216,0.0002342367,0.0002780034,0.0003975383,0.0003175015,0.000406575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001209818,"about_ca_system_score_gemma":0.0008074185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.07169549,"about_ca_topic_score_gemma":0.1744778,"domain_scores_codex":[0.9997469,0.00001879178,0.00001399745,0.00008409195,0.00007299982,0.00006323949],"domain_scores_gemma":[0.9996828,0.00004201824,0.00009176079,0.00002905493,0.00009238396,0.00006208627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001159482,0.0001465875,0.3141805,0.000262758,0.0001177549,0.0006616538,0.001513669,0.001138029,0.6556865,0.0003434496,0.001494349,0.02329523],"study_design_scores_gemma":[0.00002781351,0.0005136275,0.9412565,0.00004673985,0.0000578026,0.00149848,0.001358108,0.00276052,0.04847343,0.0001619277,0.003818988,0.00002602313],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971942,0.0002744017,0.0005021392,0.00004435787,0.000004123077,0.00002567173,0.000752564,0.00001883606,0.001183628],"genre_scores_gemma":[0.9951885,0.0002071391,0.001438347,0.00006029529,0.000003946472,0.00002726912,0.001736521,0.000008078144,0.001330046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07169549,"threshold_uncertainty_score":0.1425564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01370327697951764,"score_gpt":0.2477487846863717,"score_spread":0.234045507706854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}