{"id":"W2610847176","doi":"10.1021/acschembio.7b00203","title":"Iron Uptake Oxidoreductase (IruO) Uses a Flavin Adenine Dinucleotide Semiquinone Intermediate for Iron-Siderophore Reduction","year":2017,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Porphyrin Metabolism and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; University of British Columbia","keywords":"Siderophore; Flavin adenine dinucleotide; Oxidoreductase; Cofactor; Semiquinone; Chemistry; Flavin group; Nicotinamide adenine dinucleotide phosphate; Ferrichrome; Reductase; Enzyme kinetics; Biochemistry; Stereochemistry; Flavoprotein; NAD+ kinase; Enzyme; Active site; Oxidase test; Escherichia coli; Quinone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000175531,0.0003066566,0.0003440419,0.00004446942,0.000211427,0.00004854151,0.0006242287,0.0004358772,0.00003631059],"category_scores_gemma":[0.0007449044,0.0002772968,0.0001812968,0.00003373672,0.0006466737,0.0000143717,0.0003615051,0.0001660154,0.00002234327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001644918,"about_ca_system_score_gemma":0.00005895654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004705849,"about_ca_topic_score_gemma":0.000009479741,"domain_scores_codex":[0.9982632,0.00004361136,0.0003641915,0.0007232456,0.00007472016,0.0005310065],"domain_scores_gemma":[0.9985978,0.00002295445,0.0002646343,0.0008539105,0.00008701617,0.000173699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004107829,0.00009580704,0.0007585865,0.00002958493,0.00003911901,0.000002223899,0.00003024597,0.00000136795,0.980737,0.0001729379,0.01014327,0.007579048],"study_design_scores_gemma":[0.001614044,0.0002544197,0.001803144,0.00001317931,0.00006236924,0.00004006922,0.00007470887,0.000006798802,0.9521163,0.0009697365,0.04267468,0.0003705068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962357,0.001321079,0.0001603404,0.000797253,0.0006620786,0.000323092,0.0001820801,0.00003145251,0.0002868925],"genre_scores_gemma":[0.9944896,0.000844713,0.001404483,0.000350617,0.001188134,0.0001153856,0.001210589,0.00004251545,0.0003540368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03253141,"threshold_uncertainty_score":0.9999679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01411262432798135,"score_gpt":0.2804195700009527,"score_spread":0.2663069456729714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}