{"id":"W2610936921","doi":"10.1186/s13578-017-0150-x","title":"Gene expression profiling discerns molecular pathways elicited by ligand signaling to enhance the specification of embryonic stem cells into skeletal muscle lineage","year":2017,"lang":"en","type":"review","venue":"Cell & Bioscience","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Myogenesis; Biology; Cell biology; Embryonic stem cell; Stem cell; Cellular differentiation; Progenitor cell; Signal transduction; Gene expression profiling; Skeletal muscle; Mesoderm; Transcriptome; Myocyte; Genetics; Gene expression; Endocrinology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000646685,0.0003230839,0.0004361116,0.00007331856,0.0003064327,0.00005307744,0.0009135999,0.0003587347,0.000002389526],"category_scores_gemma":[0.00002814047,0.0002265991,0.0002010214,0.0002085677,0.0002433914,0.000009873205,0.0003408146,0.0001584397,0.00002060725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003659361,"about_ca_system_score_gemma":0.0001903128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003291941,"about_ca_topic_score_gemma":0.000001700079,"domain_scores_codex":[0.998056,0.0001228517,0.0004966,0.0007899582,0.0002243856,0.0003102008],"domain_scores_gemma":[0.9983732,0.00002787274,0.0006395486,0.0007717366,0.00008717384,0.0001005085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000003765172,0.00002990466,0.000002407948,0.0004285312,0.000007465671,9.054419e-7,0.00004562294,0.000006964152,0.8610041,0.000001289475,0.00005876276,0.1384103],"study_design_scores_gemma":[0.00003825098,0.00007646613,0.000006875288,0.000500199,0.00002998711,0.000001692726,0.0000227504,0.000004495097,0.8197671,0.000001819915,0.1793158,0.0002346681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.153991,0.8352387,0.009152345,0.00001649626,0.0003642548,0.001017054,0.00009632415,0.00001259291,0.0001112195],"genre_scores_gemma":[0.1694259,0.8253988,0.003236268,0.00005726775,0.0001732902,0.0000867334,0.0006291858,0.0000469749,0.0009456136],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.179257,"threshold_uncertainty_score":0.9240444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02529263369399152,"score_gpt":0.3012481139349718,"score_spread":0.2759554802409803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}