{"id":"W2610948238","doi":"10.1016/j.freeradbiomed.2017.05.005","title":"Differential redox sensitivity of cathepsin B and L holds the key to autophagy-apoptosis interplay after Thioredoxin reductase inhibition in nutritionally stressed SH-SY5Y cells","year":2017,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Autophagy; Thioredoxin reductase; Cell biology; Programmed cell death; Oxidative stress; Cathepsin B; Apoptosis; Cathepsin; Cathepsin L; Thioredoxin; Cathepsin D; Biology; Lysosome; Downregulation and upregulation; Chemistry; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002034648,0.0002050802,0.0005632559,0.0001479205,0.0003015369,0.0005580569,0.0002495709,0.0003868426,0.001311306],"category_scores_gemma":[0.0001509967,0.0001528431,0.0003831972,0.0002509953,0.0004431597,0.0004597963,0.0002189856,0.0006802165,0.0002642124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005253842,"about_ca_system_score_gemma":0.0003656341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002022747,"about_ca_topic_score_gemma":0.002320345,"domain_scores_codex":[0.9997936,0.00002375882,0.00003200656,0.00004253658,0.00004178449,0.00006625793],"domain_scores_gemma":[0.9998968,0.0000137199,0.0000218748,0.00001857121,0.00002474365,0.00002417397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001505782,0.00004967575,0.0005253911,0.00005907614,0.00002106041,0.0001590755,0.0000929494,0.00008049372,0.9959291,0.0002024728,0.0001105823,0.001264343],"study_design_scores_gemma":[0.00003131573,0.0003292982,0.007854939,0.000005405191,0.00003199791,0.0001912492,0.0002041873,0.0006282043,0.9893666,0.0001112478,0.0012337,0.00001181269],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970766,0.001068435,0.0005342264,0.0001692762,0.0000409918,0.000007038747,0.0004173005,0.00003644169,0.000649683],"genre_scores_gemma":[0.9983218,0.0002793944,0.0002432783,0.00004551454,0.000005367198,0.000008345725,0.000305296,0.000006138518,0.0007847489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002022747,"threshold_uncertainty_score":0.004386723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01039662781616435,"score_gpt":0.2981798416132736,"score_spread":0.2877832137971092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}