{"id":"W2611004297","doi":"10.1089/hum.2016.161","title":"Overexpression of the X-Linked Inhibitor of Apoptosis Protects Against Retinal Degeneration in a Feline Model of Retinal Detachment","year":2017,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Retinal and Macular Surgery","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"National Eye Institute; National Institutes of Health; Canadian Institutes of Health Research; Macula Vision Research Foundation","keywords":"XIAP; Retinal; Retinal detachment; Retina; Inhibitor of apoptosis; Photoreceptor cell; Retinal degeneration; Apoptosis; Outer nuclear layer; Programmed cell death; Biology; Necroptosis; Pathology; Medicine; Ophthalmology; Caspase; Neuroscience; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004341926,0.0004624361,0.0006868165,0.0005365533,0.0003562424,0.0003729855,0.0003814544,0.0007560916,0.0009123519],"category_scores_gemma":[0.0003579364,0.000253307,0.0003673611,0.0001297398,0.0004995501,0.0003360594,0.0002370637,0.0009634445,0.0001574735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000712878,"about_ca_system_score_gemma":0.0003485144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002403053,"about_ca_topic_score_gemma":0.004034731,"domain_scores_codex":[0.9997477,0.00005494169,0.0000250062,0.00005549626,0.00004913105,0.00006773474],"domain_scores_gemma":[0.9996694,0.00005406653,0.000108054,0.00004241424,0.00002975584,0.00009624072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001280199,0.0009234263,0.000869188,0.0001124182,0.00003076204,0.0003712507,0.0001150357,0.0003880069,0.9926322,0.0001224459,0.0001322898,0.003022787],"study_design_scores_gemma":[0.0005559509,0.03147297,0.0290875,0.0001466935,0.0001626283,0.002391196,0.0003132217,0.00554642,0.9260665,0.000180552,0.004030932,0.00004553385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983909,0.000577636,0.0004549684,0.00009843952,0.00001826529,0.00004596906,0.00007021723,0.0000262493,0.0003174707],"genre_scores_gemma":[0.9960251,0.0008690483,0.001182706,0.00005815216,0.000009906342,0.00006477296,0.0002359094,0.000007631607,0.001546719],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002403053,"threshold_uncertainty_score":0.005172253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05706439607914297,"score_gpt":0.3104688188091467,"score_spread":0.2534044227300037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}