{"id":"W2611118767","doi":"10.1016/j.biopsych.2017.04.011","title":"β-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog–Induced Kinase 1 Transcription in Cells and in Alzheimer Mice Models","year":2017,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Ligue Contre le Cancer; Conseil Départemental des Alpes Maritimes; Agence Nationale de la Recherche; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease","keywords":"Tensin; Phosphatase; Cell biology; Intracellular; Transcription (linguistics); Function (biology); Kinase; Chemistry; Amyloid precursor protein; Biology; PTEN; Alzheimer's disease; Phosphorylation; Signal transduction; Medicine; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001676825,0.0003227859,0.0001843174,0.0003093421,0.0002422162,0.0004022457,0.0002685694,0.000283469,0.001285645],"category_scores_gemma":[0.0001345708,0.0002200998,0.0002785701,0.0001618529,0.0004447512,0.000402522,0.00021592,0.0008303856,0.0003159919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003796257,"about_ca_system_score_gemma":0.0001919617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005252595,"about_ca_topic_score_gemma":0.0009796415,"domain_scores_codex":[0.9998338,0.00002711397,0.00001325987,0.00004303677,0.00003432313,0.00004843704],"domain_scores_gemma":[0.99988,0.00000982187,0.00004844703,0.00001353035,0.000009737511,0.0000384796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007616392,0.000082436,0.0002823483,0.0000320343,0.000009675369,0.00006653383,0.00002834568,0.00005879183,0.99722,0.0003158721,0.0001286121,0.00101371],"study_design_scores_gemma":[0.0002041226,0.0004911313,0.01434451,0.00001416879,0.00009374585,0.0003465851,0.0001740995,0.002211808,0.977344,0.0006876742,0.004073017,0.00001514883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954047,0.001068464,0.001692371,0.0002747892,0.00008821066,0.00001110581,0.0003046286,0.00008349157,0.001072377],"genre_scores_gemma":[0.9962204,0.0005661254,0.000642363,0.00008089124,0.00001307639,0.00001885966,0.0002869589,0.00002527405,0.00214604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001285645,"threshold_uncertainty_score":0.004300892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03967536572211895,"score_gpt":0.2855193010398797,"score_spread":0.2458439353177607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}