{"id":"W2611131029","doi":"10.1056/nejmoa1614949","title":"Teprotumumab for Thyroid-Associated Ophthalmopathy","year":2017,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Ophthalmology and Eye Disorders","field":"Medicine","cited_by":721,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kellogg's (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Eye Institute; National Institute of Diabetes and Digestive and Kidney Diseases; U.S. Food and Drug Administration","keywords":"Medicine; Graves' ophthalmopathy; Placebo; Internal medicine; Adverse effect; Thyroid; Population; Clinical trial; Clinical endpoint; Graves' disease; Gastroenterology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001298587,0.0001559628,0.0006310304,0.0001374643,0.0002676931,0.00001407757,0.0002597272,0.0001333534,0.0002350994],"category_scores_gemma":[0.004222582,0.0001007292,0.0001526236,0.00004588483,0.0002075509,0.0001261738,0.00002286973,0.0003679312,0.00000654052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004023889,"about_ca_system_score_gemma":0.0002321491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007159278,"about_ca_topic_score_gemma":0.000006682291,"domain_scores_codex":[0.9987789,0.00004406138,0.0004715702,0.0001369578,0.000310871,0.0002576609],"domain_scores_gemma":[0.9981262,0.000208971,0.0006794838,0.000336086,0.0003422772,0.0003069662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02071391,0.001212952,0.5899771,0.0003399817,0.001806743,0.006237717,0.005104375,0.00001824194,0.01612228,0.001058296,0.1046135,0.2527949],"study_design_scores_gemma":[0.3432533,0.02337708,0.5535346,0.001655504,0.001399617,0.01969066,0.0009422702,0.0001341945,0.0009061806,0.01605026,0.03868277,0.000373601],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9567927,0.001696993,0.0004145907,0.02785502,0.001531957,0.0003548735,0.000003883575,0.00001309235,0.01133689],"genre_scores_gemma":[0.9929646,0.0001252144,0.0004419191,0.0004313514,0.003112096,0.00000329033,0.000008658744,0.00002144102,0.002891405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3225394,"threshold_uncertainty_score":0.505513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04452435748877569,"score_gpt":0.3543494066987863,"score_spread":0.3098250492100106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}