{"id":"W2611192795","doi":"10.1146/annurev-genom-091416-035434","title":"Tailoring Medulloblastoma Treatment Through Genomics: Making a Change, One Subgroup at a Time","year":2017,"lang":"en","type":"review","venue":"Annual Review of Genomics and Human Genetics","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"Health Canada; Garron Family Cancer Centre; Brain Tumour Foundation of Canada; Fondation Brain Canada; National Cancer Institute; National Institutes of Health; CureSearch for Children's Cancer","keywords":"Medulloblastoma; Genomics; Medicine; Clinical trial; Disease; Compassionate Use; Oncology; Bioinformatics; Internal medicine; Biology; Genome; Genetics; Cancer research; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001549806,0.0004729182,0.001183864,0.001120931,0.0002560052,0.001462922,0.0007125981,0.00138262,0.002310915],"category_scores_gemma":[0.002337673,0.0001494779,0.0005664647,0.00090873,0.0006191142,0.001964574,0.0008007499,0.002977158,0.001071713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008645118,"about_ca_system_score_gemma":0.001900858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001303043,"about_ca_topic_score_gemma":0.002971249,"domain_scores_codex":[0.9996456,0.0001049213,0.00004682134,0.00006261852,0.0001046674,0.00003534729],"domain_scores_gemma":[0.9990621,0.0005804007,0.00006394045,0.00002742978,0.0002024369,0.00006361007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006975955,0.00005641957,0.0005167882,0.008452732,0.0001377478,0.0001902761,0.0001109525,0.0003394991,0.001341001,0.009515392,0.0334781,0.9457913],"study_design_scores_gemma":[0.00002664912,0.00009876319,0.001051846,0.006156448,0.000173276,0.0009874894,0.000181768,0.0001448493,0.0005516539,0.008829817,0.9817742,0.00002329708],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002564693,0.9919471,0.0005387423,0.005338827,0.0005420691,0.000009206925,0.0000403238,0.00001995088,0.001307294],"genre_scores_gemma":[0.002014604,0.9937417,0.0008627776,0.002227405,0.0005294198,0.00001302186,0.00006618016,0.000006725065,0.0005381908],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002310915,"threshold_uncertainty_score":0.008196294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1435628598881593,"score_gpt":0.3894866764033723,"score_spread":0.2459238165152131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}