{"id":"W2611199637","doi":"10.1161/str.47.suppl_1.212","title":"Abstract 212: Andexanet Alfa, a Universal Antidote for Reversal of Anticoagulation of Factor Xa Inhibitors in Healthy Human Volunteers","year":2016,"lang":"en","type":"article","venue":"Stroke","topic":"Atrial Fibrillation Management and Outcomes","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; St. Joseph’s Healthcare Hamilton","funders":"","keywords":"Medicine; Bolus (digestion); Antidote; Placebo; Pharmacology; Anesthesia; Rivaroxaban; Randomization; Urology; Internal medicine; Clinical trial; Toxicity; Warfarin; Atrial fibrillation; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001327319,0.000572417,0.0005579872,0.0002137624,0.0002475957,0.0003469138,0.0002290164,0.0004982275,0.01047585],"category_scores_gemma":[0.001050965,0.0001173044,0.0003595614,0.0001627452,0.0002015584,0.000231429,0.0002526464,0.0004130719,0.001549424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001893551,"about_ca_system_score_gemma":0.0003755532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002146709,"about_ca_topic_score_gemma":0.0001756508,"domain_scores_codex":[0.9993554,0.0003115003,0.00006913372,0.0001276951,0.00008003927,0.00005633539],"domain_scores_gemma":[0.9994044,0.0001380666,0.0001454298,0.00005396412,0.0001124316,0.0001455654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4066392,0.01335339,0.05161627,0.00375738,0.001056836,0.0008646451,0.0002562471,0.0002813253,0.0983857,0.0003277563,0.02323576,0.4002256],"study_design_scores_gemma":[0.1191814,0.4997544,0.2642188,0.0004662936,0.001824219,0.004185849,0.0001460746,0.001023565,0.06286146,0.0004497,0.04583023,0.00005801908],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9692165,0.01397549,0.001741694,0.0009376589,0.0006600301,0.002545111,0.002926699,0.0002909917,0.007705793],"genre_scores_gemma":[0.980492,0.003139473,0.002002397,0.001142986,0.0006462766,0.001157806,0.002849449,0.00002542105,0.008544192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01047585,"threshold_uncertainty_score":0.03504521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05348285319924062,"score_gpt":0.3395131153575764,"score_spread":0.2860302621583358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}