{"id":"W2611203865","doi":"10.1002/pro.3181","title":"Refolding the unfoldable: A systematic approach for renaturation of<i>Bacillus circulans</i>xylanase","year":2017,"lang":"en","type":"article","venue":"Protein Science","topic":"Biofuel production and bioconversion","field":"Engineering","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"British Columbia Knowledge Development Fund; Natural Sciences and Engineering Research Council of Canada; Deutsche Forschungsgemeinschaft; Canada Foundation for Innovation","keywords":"Bacillus circulans; Chemistry; Xylanase; Biochemistry; Biocatalysis; Clostridium thermocellum; Residue (chemistry); Enzyme; Combinatorial chemistry; Cellulase; Computational biology; Catalysis; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008352762,0.0008459633,0.0007386362,0.0004328776,0.0003807913,0.0006540396,0.0005085851,0.0003757345,0.0003618161],"category_scores_gemma":[0.0007982628,0.0003378807,0.0005439358,0.0004473683,0.0004139462,0.0005699052,0.0007054527,0.001105902,0.0003459682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005179338,"about_ca_system_score_gemma":0.0007212232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001142162,"about_ca_topic_score_gemma":0.001861807,"domain_scores_codex":[0.9993287,0.000156793,0.00008163238,0.0001680093,0.0001835898,0.00008125863],"domain_scores_gemma":[0.9996216,0.00006179804,0.0001161407,0.00008934752,0.00007561978,0.00003529488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000344306,0.00004873864,0.0001048766,0.00007609613,0.000008703011,0.00003746185,0.00003833114,0.0003454508,0.993859,0.000127765,0.00003513078,0.005284036],"study_design_scores_gemma":[0.000005382918,0.0002186625,0.0004722753,0.000009466489,0.00001906691,0.0001148448,0.00001835004,0.0006339818,0.9963213,0.0000515143,0.00212371,0.00001138065],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8590879,0.004766501,0.1301799,0.0003365452,0.00007521233,0.0008663142,0.0006870225,0.0007139221,0.003286732],"genre_scores_gemma":[0.8088959,0.006679939,0.1783686,0.0001662794,0.00003100815,0.0003548076,0.001851985,0.000373045,0.003278367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001142162,"threshold_uncertainty_score":0.00441736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02308238357470689,"score_gpt":0.2392841068660015,"score_spread":0.2162017232912947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}