{"id":"W2611244208","doi":"10.1371/journal.pone.0182194","title":"Changes in lipid membranes may trigger amyloid toxicity in Alzheimer's disease","year":2017,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Keysight Technologies; Waterloo Institute for Nanotechnology, University of Waterloo; National Institute of Advanced Industrial Science and Technology; Heart and Stroke Foundation of Canada; University of Toronto; American Heart Association","keywords":"Membrane; Lipid bilayer; Amyloid (mycology); Toxicity; Biophysics; Chemistry; Biological membrane; Cell biology; Amyloid beta; Alzheimer's disease; Biochemistry; Peptide; Biology; Medicine; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001207125,0.0001699557,0.0002367074,0.0000661466,0.00008325696,0.00004454366,0.0003429245,0.0001372894,0.0000822529],"category_scores_gemma":[0.0001117058,0.0001551224,0.000053117,0.0000408171,0.00008744685,0.000009109029,0.0001384807,0.0001209242,0.0000132015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009661228,"about_ca_system_score_gemma":0.00004908271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007956366,"about_ca_topic_score_gemma":0.001467956,"domain_scores_codex":[0.9989747,0.00004309921,0.0001607286,0.000368238,0.0001652505,0.0002879848],"domain_scores_gemma":[0.9990966,0.0000072488,0.00008492922,0.0006551381,0.0000330589,0.00012308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001848851,0.0005754819,0.06511141,0.00005328756,0.00005032801,0.00002050768,0.0000327242,0.00000130396,0.9327307,0.000009089581,0.00004313475,0.001187094],"study_design_scores_gemma":[0.0007601546,0.00007077421,0.1337371,0.00006098632,0.00009252407,8.381332e-7,0.000009698904,0.000007221081,0.863918,0.00001108107,0.001132957,0.0001986601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968214,0.0004209167,3.2161e-7,0.001636715,0.0001045745,0.0002988429,0.0000363971,0.0000105151,0.0006703151],"genre_scores_gemma":[0.9978781,0.0004719988,0.00007261711,0.0002626599,0.0006097524,0.00006737577,0.00006307735,0.00002232588,0.0005520537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06881277,"threshold_uncertainty_score":0.6325706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03959054679547128,"score_gpt":0.2682797338313418,"score_spread":0.2286891870358705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}