{"id":"W2611244208","doi":"10.1371/journal.pone.0182194","title":"Changes in lipid membranes may trigger amyloid toxicity in Alzheimer's disease","year":2017,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Keysight Technologies; Waterloo Institute for Nanotechnology, University of Waterloo; National Institute of Advanced Industrial Science and Technology; Heart and Stroke Foundation of Canada; University of Toronto; American Heart Association","keywords":"Membrane; Lipid bilayer; Amyloid (mycology); Toxicity; Biophysics; Chemistry; Biological membrane; Cell biology; Amyloid beta; Alzheimer's disease; Biochemistry; Peptide; Biology; Medicine; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001815131,0.0002502707,0.0001786468,0.0002170223,0.0002427443,0.0002788935,0.000110489,0.0004428926,0.0004751123],"category_scores_gemma":[0.0002452006,0.0001675813,0.0001611587,0.0001164837,0.0002836764,0.0006244575,0.0003044202,0.0003789277,0.0001528335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002463385,"about_ca_system_score_gemma":0.00009337199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001819945,"about_ca_topic_score_gemma":0.0001634365,"domain_scores_codex":[0.9999341,0.00001591216,0.000005657911,0.00001110188,0.00002031917,0.00001298145],"domain_scores_gemma":[0.9999256,0.00001173873,0.00003216973,0.000005952647,0.00001224322,0.00001226073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001304789,0.00001562295,0.000677528,0.00003391456,0.00000503538,0.000213762,0.00004402423,0.00009335853,0.9969728,0.0002537663,0.00002238085,0.001537303],"study_design_scores_gemma":[0.00002528877,0.0003561737,0.02476131,0.00002051467,0.00003044381,0.001549776,0.0002068118,0.001594863,0.9672034,0.002313067,0.00191893,0.00001947313],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950824,0.001594918,0.002311892,0.0001368175,0.00001928271,0.00001179807,0.00004800435,0.00003430644,0.0007605985],"genre_scores_gemma":[0.9979315,0.0008654737,0.0007986447,0.00006376882,0.000005055381,0.00001167925,0.00002897744,0.000004291687,0.0002907206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004751123,"threshold_uncertainty_score":0.001787245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03959054679547128,"score_gpt":0.2682797338313418,"score_spread":0.2286891870358705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}