{"id":"W2611252707","doi":"10.1200/jco.2007.25.18_suppl.7571","title":"Updated molecular analyses of exons 19 and 21 of the epidermal growth factor receptor (<i>EGFR</i>) gene and codons 12 and 13 of the <i>KRAS</i> gene in non-small cell lung cancer (NSCLC) patients treated with erlotinib in National Cancer Institute of Cancer","year":2007,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"KRAS; Exon; Gefitinib; Epidermal growth factor receptor; Erlotinib; Polysomy; Molecular biology; Medicine; Copy-number variation; Gene; EGFR inhibitors; Point mutation; Cancer research; Cancer; Biology; Mutation; Internal medicine; Genetics; Fluorescence in situ hybridization; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006730372,0.0004353754,0.0004707674,0.001956859,0.0002529648,0.0006284383,0.0006444959,0.0007319242,0.001551118],"category_scores_gemma":[0.001312441,0.0003015196,0.0003534175,0.0008132941,0.0002442675,0.0003285589,0.0002092746,0.0005454869,0.0004289903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000679703,"about_ca_system_score_gemma":0.0003338945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003294341,"about_ca_topic_score_gemma":0.007568884,"domain_scores_codex":[0.9994816,0.00008436213,0.0001040852,0.00009175677,0.0001661519,0.00007198026],"domain_scores_gemma":[0.9992724,0.0001589294,0.0001938467,0.00003645096,0.0002208596,0.000117533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002276557,0.0002388797,0.8511431,0.0002540176,0.0002552018,0.005231779,0.000226653,0.0006755732,0.0562357,0.0001350753,0.008331252,0.07499627],"study_design_scores_gemma":[0.0000619261,0.0004121277,0.9641092,0.00002530527,0.0002997724,0.01553338,0.0001048876,0.0006188959,0.01162635,0.00005297048,0.007140874,0.00001418366],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814349,0.009888518,0.0006916568,0.0007334037,0.0001049172,0.00005168237,0.002784265,0.000105308,0.004205358],"genre_scores_gemma":[0.9876884,0.002566745,0.002077263,0.0004800444,0.0001215475,0.00003564841,0.00547009,0.00002284686,0.001537455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003294341,"threshold_uncertainty_score":0.006550372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05193385057218633,"score_gpt":0.4314486379709473,"score_spread":0.379514787398761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}