{"id":"W2611351680","doi":"10.1007/s00401-017-1716-8","title":"Reappraisal of TDP-43 pathology in FTLD-U subtypes","year":2017,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":120,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver General Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Consortium canadien en neurodégénérescence associée au vieillissement","keywords":"Frontotemporal lobar degeneration; Immunohistochemistry; Pathology; Pathological; Ubiquitin; Biology; Medicine; Dementia; Frontotemporal dementia; Disease; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005135946,0.0001660525,0.0004738617,0.0001285464,0.0001228708,0.00002711778,0.0005103864,0.00017656,0.0002376196],"category_scores_gemma":[0.002525349,0.0001204782,0.00009418843,0.0001026522,0.0005311422,0.0001249904,0.0003973116,0.0004799917,0.00007126956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001551173,"about_ca_system_score_gemma":0.00005582525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005590847,"about_ca_topic_score_gemma":0.00001130095,"domain_scores_codex":[0.9982352,0.0002396872,0.0003516907,0.0004485422,0.0002927659,0.0004321078],"domain_scores_gemma":[0.9982956,0.0001388566,0.0002132153,0.001136077,0.00009543759,0.0001208253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004035225,0.0002647578,0.3454162,0.00003907638,0.000005883489,0.004652196,0.0001265601,8.249913e-7,0.6437675,0.0003649396,0.000325228,0.004633329],"study_design_scores_gemma":[0.001013411,0.0008240964,0.9912421,0.0000459974,0.00001291179,0.0004064146,0.0000118839,0.00002939772,0.004249291,0.0001251705,0.00193658,0.000102807],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775992,0.00005514044,0.000004271974,0.004304119,0.0001468368,0.0002765688,0.000007361494,0.00004420754,0.01756231],"genre_scores_gemma":[0.9983453,0.0003254824,0.0003741791,0.0003362403,0.00009226624,0.00001988207,0.000005922904,0.000024214,0.0004764914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6458259,"threshold_uncertainty_score":0.4912958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05752428327238156,"score_gpt":0.3523255038682118,"score_spread":0.2948012205958302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}