{"id":"W2611357663","doi":"10.1038/s41598-017-01825-x","title":"Tumor suppressor menin is required for subunit-specific nAChR α5 transcription and nAChR-dependent presynaptic facilitation in cultured mouse hippocampal neurons","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates; Alberta Innovates - Health Solutions; University of Calgary","keywords":"Glutamatergic; MEN1; Neuroscience; Cholinergic; Biology; Hippocampal formation; Synaptic plasticity; Protein subunit; Cell biology; Glutamate receptor; Receptor; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001059179,0.0002388854,0.0002534203,0.00009042353,0.0005865206,0.0003730704,0.0002750147,0.000139631,0.00002395317],"category_scores_gemma":[0.0003911656,0.0002298233,0.0001226844,0.00006872343,0.0003386454,0.00004736183,0.0001257107,0.0001229144,0.000004938242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003912432,"about_ca_system_score_gemma":0.00008872784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000040483,"about_ca_topic_score_gemma":0.0001832863,"domain_scores_codex":[0.9974346,0.00009562181,0.0005691419,0.001153394,0.000338386,0.0004088228],"domain_scores_gemma":[0.9980687,0.00001560588,0.0003883827,0.00120616,0.0001892018,0.0001319171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001141277,0.0001323282,0.001318389,0.00003631676,0.00002480365,0.000007811929,0.0008773408,0.00002057058,0.9887414,0.0000103949,0.008032917,0.0006836079],"study_design_scores_gemma":[0.001303556,0.0002273947,0.00154924,0.00002608812,0.00003274337,0.00008756891,0.0004352612,0.0001925516,0.9547729,0.0003650301,0.04066824,0.0003393758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952868,0.0005136429,0.0004786473,0.0002650126,0.002062376,0.001156066,0.00007242063,0.00002316008,0.0001419076],"genre_scores_gemma":[0.9930436,0.00004278548,0.0007232993,0.00002749527,0.0001086758,0.0001611043,0.0003108158,0.00002959545,0.005552655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03396844,"threshold_uncertainty_score":0.9371924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02432059669100735,"score_gpt":0.2819290032527212,"score_spread":0.2576084065617139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}