{"id":"W2611439401","doi":"10.1158/1535-7163.mct-16-0819","title":"Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors","year":2017,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Food science; Substrate (aquarium); Chemistry; Biochemistry; Biology; Ecology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000238448,0.0004551076,0.0004062525,0.0003390095,0.0001420021,0.0003035213,0.0003771364,0.0002315409,0.001157902],"category_scores_gemma":[0.000195354,0.0001261786,0.0002943941,0.0002411203,0.0001051478,0.0002267083,0.000154008,0.0004487203,0.0005366643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003056058,"about_ca_system_score_gemma":0.0002843577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003657729,"about_ca_topic_score_gemma":0.001233862,"domain_scores_codex":[0.9998838,0.00002279623,0.00001226128,0.00001937265,0.00004244357,0.000019384],"domain_scores_gemma":[0.9999255,0.00001004727,0.00001529098,0.000009735679,0.00001903425,0.00002036651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002087422,0.0002200369,0.0004290833,0.0001093318,0.00002558496,0.000125985,0.00002396995,0.0004821353,0.9812155,0.0003641348,0.0002273722,0.01656805],"study_design_scores_gemma":[0.0001342412,0.002152067,0.002004884,0.00001730923,0.00007747994,0.0007999933,0.00002456963,0.00231309,0.9764261,0.0001164537,0.01592066,0.00001320288],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9423014,0.01725368,0.02710698,0.0003349455,0.0001008298,0.0008003783,0.001706598,0.0002029635,0.01019226],"genre_scores_gemma":[0.9594951,0.00770006,0.02291664,0.0001913172,0.0000447229,0.0002171356,0.0034495,0.000051081,0.005934478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001157902,"threshold_uncertainty_score":0.003873587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02936548373320665,"score_gpt":0.3017219061666139,"score_spread":0.2723564224334072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}