{"id":"W2611521643","doi":"10.25011/cim.v31i4.4811","title":"LACK OF CELLULAR PRION PROTEIN UNMASKS NMDA NR2D SUBUNIT RECEPTOR FUNCTION WITH CONSEQUENCES TOWARD SYNAPTIC TRANSMISSION AND EXCITOTOXICITY","year":2008,"lang":"en","type":"article","venue":"Clinical and investigative medicine","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Excitotoxicity; Neurotransmission; NMDA receptor; Glutamatergic; Kainic acid; Long-term potentiation; Neuroscience; Biology; AMPA receptor; Excitatory postsynaptic potential; Hippocampal formation; Slice preparation; Synaptic plasticity; Glutamate receptor; Cell biology; Electrophysiology; Receptor; Biochemistry; Inhibitory postsynaptic potential","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002302403,0.0004279373,0.0002710029,0.0002109846,0.0001680545,0.0003163383,0.0003563128,0.000432433,0.001421809],"category_scores_gemma":[0.0002898072,0.0001633996,0.0002679875,0.000111004,0.0004959166,0.0002547493,0.0002234914,0.0007652937,0.0004018743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002564215,"about_ca_system_score_gemma":0.000168399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003102382,"about_ca_topic_score_gemma":0.0006593896,"domain_scores_codex":[0.9997749,0.00003021099,0.00005267367,0.00004203983,0.0000625219,0.00003759754],"domain_scores_gemma":[0.9996943,0.00005346498,0.0001097939,0.00005030072,0.00002563351,0.00006648611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009534757,0.00003892162,0.0002114491,0.00002913469,0.000005710655,0.0001516542,0.00001171781,0.00002063381,0.9988054,0.00006017259,0.00002388461,0.0005458934],"study_design_scores_gemma":[0.00007310655,0.0008463296,0.01377439,0.00002402105,0.00005184515,0.002539147,0.00007177785,0.001141696,0.9795623,0.0001455473,0.001760197,0.000009702363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969724,0.0005663834,0.001538177,0.00009919893,0.00002974387,0.00002048937,0.0001861653,0.00004608816,0.0005413671],"genre_scores_gemma":[0.9969707,0.0004250221,0.001269026,0.00005704333,0.0000162269,0.00003700556,0.0003015694,0.00002738914,0.000896016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001421809,"threshold_uncertainty_score":0.004756451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1539531200870816,"score_gpt":0.3195931186267792,"score_spread":0.1656399985396976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}