{"id":"W2611548364","doi":"10.1056/nejmoa1606910","title":"Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis","year":2017,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1727,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Robarts Clinical Trials; Western University","funders":"Pfizer","keywords":"Tofacitinib; Ulcerative colitis; Medicine; Janus kinase inhibitor; Maintenance therapy; Induction therapy; Janus kinase; Colitis; Internal medicine; Gastroenterology; Chemotherapy; Receptor; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002337147,0.0003974616,0.001441281,0.0004396769,0.0002565513,0.0005802792,0.0006261772,0.0008888922,0.002842339],"category_scores_gemma":[0.001307977,0.0001751881,0.0009230171,0.000428559,0.000466516,0.0005885945,0.0003090441,0.001944791,0.0004069886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006414204,"about_ca_system_score_gemma":0.0005628325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002623053,"about_ca_topic_score_gemma":0.0007963045,"domain_scores_codex":[0.9993078,0.0002900646,0.00008349901,0.0001036734,0.0001262923,0.00008875473],"domain_scores_gemma":[0.9990001,0.000313842,0.000301484,0.00008072299,0.00006039205,0.0002434034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3510164,0.008184032,0.006935567,0.003155465,0.001362862,0.0002073825,0.0001755158,0.001049693,0.01587702,0.0005712805,0.004583619,0.6068812],"study_design_scores_gemma":[0.6245748,0.3062592,0.03451246,0.0009856981,0.002125513,0.001394568,0.00006785703,0.001845104,0.009060729,0.0007387365,0.01837272,0.00006266867],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8955723,0.09324562,0.001242311,0.001668804,0.0003770557,0.001415773,0.0008170121,0.0001915032,0.005469649],"genre_scores_gemma":[0.9792723,0.01417792,0.001736945,0.001217754,0.0004209398,0.0011182,0.0009551051,0.00001381562,0.0010869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002842339,"threshold_uncertainty_score":0.01236016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01712734440931054,"score_gpt":0.2945029057821552,"score_spread":0.2773755613728447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}