{"id":"W2611582655","doi":"10.1007/s13346-017-0379-2","title":"Mechanistically elucidating the in vitro safety and efficacy of a novel doxorubicin derivative","year":2017,"lang":"en","type":"article","venue":"Drug Delivery and Translational Research","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Boniface Hospital; University of Alberta; University of Manitoba","funders":"National Cancer Institute","keywords":"Doxorubicin; Pharmacology; Cardiotoxicity; Oxidative stress; CYP3A4; Chemistry; Reactive oxygen species; Bioavailability; Biochemistry; Biology; Toxicity; Medicine; Cytochrome P450; Chemotherapy; Enzyme; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001465348,0.00006891337,0.0001645926,0.0000874559,0.000384885,0.00004918079,0.00008389515,0.00005919261,0.00001154878],"category_scores_gemma":[0.0004470687,0.00005213058,0.00003520031,0.00009075219,0.0003536282,0.0001438906,0.0000339037,0.0003499291,5.937794e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001573173,"about_ca_system_score_gemma":0.0001206532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002047182,"about_ca_topic_score_gemma":0.00005465564,"domain_scores_codex":[0.9989575,0.0000813131,0.0001870078,0.0001810331,0.0004232569,0.0001699044],"domain_scores_gemma":[0.99846,0.001073923,0.00004377646,0.0001674707,0.0001905106,0.00006433896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002259619,0.0001195188,0.0009760151,0.00007211616,0.00005617087,0.000006663958,0.002064202,0.00001429521,0.9287507,0.01108591,0.000004240444,0.05459056],"study_design_scores_gemma":[0.00765752,0.00009402498,0.3112094,0.0002998842,0.00003259839,0.00002842091,0.0006411062,0.009769307,0.6661425,0.003750067,0.0002587307,0.0001163836],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890117,0.0001722265,0.002334112,0.005570919,0.00001129704,0.0004021653,0.00003508007,0.000004363723,0.002458108],"genre_scores_gemma":[0.9985551,0.0001905743,0.001039574,0.00007721485,0.00005457707,0.00000703435,0.0000224253,0.000006795016,0.00004673145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3102334,"threshold_uncertainty_score":0.2960263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06967339865206511,"score_gpt":0.3664315013801978,"score_spread":0.2967581027281326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}