{"id":"W2611685221","doi":"10.1016/j.molmet.2017.04.009","title":"A high-content small molecule screen identifies novel inducers of definitive endoderm","year":2017,"lang":"en","type":"article","venue":"Molecular Metabolism","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Bundesministerium für Bildung und Forschung; European Commission; Stem Cell Network","keywords":"Endoderm; Inducer; Cell biology; Small molecule; Computational biology; Chemistry; Biology; Genetics; Gene; Cellular differentiation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002417914,0.0008710872,0.0005830006,0.001061478,0.0002328704,0.0003610723,0.0003671485,0.0004278127,0.002671412],"category_scores_gemma":[0.0002341887,0.0002182641,0.0005178193,0.0006762852,0.0002176917,0.0002354023,0.0003114865,0.0004219766,0.0006798925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003421174,"about_ca_system_score_gemma":0.0005073154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004857621,"about_ca_topic_score_gemma":0.002013735,"domain_scores_codex":[0.999821,0.00002202364,0.00001647124,0.000038635,0.00007529573,0.00002661198],"domain_scores_gemma":[0.9998481,0.00003863417,0.00003004121,0.00001187301,0.00003283286,0.00003853316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001964383,0.0003037932,0.0005519369,0.0002775561,0.0000511762,0.0002654388,0.00001961099,0.0006912126,0.9851632,0.0001104733,0.000284856,0.01208434],"study_design_scores_gemma":[0.0003793207,0.005902888,0.007922422,0.00005938487,0.000319161,0.0007886099,0.00005291576,0.001415702,0.9737797,0.0001103995,0.00923348,0.000035963],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9659443,0.007184938,0.011097,0.0004788157,0.00006679742,0.001035393,0.004885354,0.0006046698,0.008702804],"genre_scores_gemma":[0.9608535,0.009276341,0.01390725,0.0005953612,0.00003280447,0.0005662807,0.006208793,0.00007734535,0.008482327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002671412,"threshold_uncertainty_score":0.008936763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06003865855618282,"score_gpt":0.2650947488681645,"score_spread":0.2050560903119817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}