{"id":"W2611690370","doi":"10.1007/s13402-017-0323-y","title":"Synthetic lethal targeting of RNF20 through PARP1 silencing and inhibition","year":2017,"lang":"en","type":"article","venue":"Cellular Oncology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Canadian Institutes of Health Research; CancerCare Manitoba Foundation; University of Bristol; Manitoba Health Research Council","keywords":"PARP1; Olaparib; Gene silencing; RNA interference; DNA damage; Carcinogenesis; Apoptosis; Programmed cell death; Biology; Synthetic lethality; Cell biology; Cancer research; Cell; DNA repair; Poly ADP ribose polymerase; Cancer; DNA; Biochemistry; Genetics; Polymerase; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003935594,0.0001211357,0.000383907,0.00004689572,0.0002194605,0.00001297882,0.00007290465,0.0001790732,0.0002354396],"category_scores_gemma":[0.0002174088,0.0001162588,0.000068519,0.00003270191,0.0004534178,0.0001204786,0.00006736568,0.0002056509,0.0000202578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001230559,"about_ca_system_score_gemma":0.0001279482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000834564,"about_ca_topic_score_gemma":0.000004533445,"domain_scores_codex":[0.9989679,0.0000826187,0.0003162713,0.0002690076,0.000146431,0.0002177344],"domain_scores_gemma":[0.9989952,0.0001120392,0.0003420943,0.0003844181,0.00009323115,0.00007301961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001440277,0.00009650024,0.002188161,0.0001404572,0.00003590655,0.0001700148,0.001166747,0.000003826051,0.990084,0.0009763607,0.0006515233,0.004342481],"study_design_scores_gemma":[0.002740826,0.0006391765,0.001437084,0.0002828134,0.00009009776,0.0001583086,0.0004884165,0.0001690395,0.976862,0.002344461,0.01464089,0.0001468534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9762212,0.001363855,0.002365427,0.001998881,0.0003682436,0.0002506888,0.000005883197,0.00003343946,0.01739237],"genre_scores_gemma":[0.995955,0.000234122,0.002984245,0.0002917827,0.0003146151,0.00002292202,0.00001376842,0.000021075,0.0001623906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01973386,"threshold_uncertainty_score":0.4740895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04226399867575973,"score_gpt":0.3460655269567079,"score_spread":0.3038015282809481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}