{"id":"W2611967614","doi":"10.1021/jacs.7b00513","title":"Designing Peptide and Protein Modified Hydrogels: Selecting the Optimal Conjugation Strategy","year":2017,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":154,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Self-healing hydrogels; Chemistry; Biomolecule; Peptide; Protein engineering; Click chemistry; Tissue engineering; Drug delivery; Extracellular matrix; Combinatorial chemistry; Amino acid; Nanotechnology; Biochemistry; Biophysics; Enzyme; Organic chemistry; Biomedical engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002822008,0.0001213442,0.0001971,0.000002534683,0.0007055792,0.0001565887,0.0006319555,0.0000541605,0.00001561654],"category_scores_gemma":[0.000269795,0.00007370929,0.0002340806,0.00006086014,0.0006188223,0.0001047464,0.0001447801,0.0005981572,5.120301e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007286065,"about_ca_system_score_gemma":0.00006920428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003107236,"about_ca_topic_score_gemma":3.616976e-7,"domain_scores_codex":[0.9991589,0.00001637687,0.0002887679,0.0001357779,0.0002174313,0.0001827036],"domain_scores_gemma":[0.9981053,0.0001532693,0.001224032,0.0003505818,0.00009109706,0.00007571958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000195168,0.00002637257,0.0004459483,0.00001685145,0.00006715369,4.722481e-7,0.0002328176,0.0001116211,0.9968392,0.00002109945,0.0005605348,0.001658444],"study_design_scores_gemma":[0.0002663931,0.0000100674,0.0001813128,0.00005978282,0.00005264298,0.00006925972,0.001284768,0.001430717,0.9956921,0.0003802808,0.0004744277,0.00009820049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957382,0.00003923802,0.000367818,0.002253894,0.000007824823,0.00005378342,0.000003408008,0.00001125238,0.001524568],"genre_scores_gemma":[0.9970355,0.00001901062,0.002192046,0.000111493,0.000329034,0.000007106671,7.486229e-7,0.00001246947,0.0002926128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002142401,"threshold_uncertainty_score":0.5426816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02544018206183929,"score_gpt":0.2825497724724466,"score_spread":0.2571095904106073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}