{"id":"W2612138077","doi":"10.1200/jco.2014.32.15_suppl.tps9121","title":"MIKIE: A randomized, double-blind, regimen-controlled, phase II, multicenter study to assess the efficacy and safety of two different vismodegib regimens in patients with multiple basal cell carcinomas.","year":2014,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Vismodegib; Medicine; Regimen; Basal cell carcinoma; Internal medicine; Oncology; Placebo; Urology; Surgery; Pathology; Basal cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002054692,0.001750743,0.002746563,0.0005092055,0.0005408595,0.001005869,0.001153946,0.001704997,0.007221535],"category_scores_gemma":[0.001424459,0.0008502168,0.001375933,0.0004440374,0.001002755,0.001359384,0.0005489078,0.003054201,0.001160164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008815129,"about_ca_system_score_gemma":0.001789218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007031618,"about_ca_topic_score_gemma":0.002054319,"domain_scores_codex":[0.9993844,0.000255815,0.00003574844,0.0001556973,0.00006199934,0.0001064017],"domain_scores_gemma":[0.9989128,0.0001799744,0.0002750375,0.00009618017,0.00006869932,0.0004672454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9356873,0.03226849,0.00177919,0.0004541931,0.0008592196,0.00004218285,0.00006763795,0.0003821169,0.008793129,0.0001234845,0.001315085,0.01822801],"study_design_scores_gemma":[0.8874235,0.1081704,0.002654081,0.00001724449,0.000258774,0.00004156418,0.0000194396,0.0002362836,0.00043192,0.00006309588,0.0006702054,0.00001356576],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816002,0.002835716,0.001005158,0.0006280745,0.0002840939,0.009036703,0.00189581,0.0001811658,0.002533089],"genre_scores_gemma":[0.966849,0.001998751,0.004400523,0.002289489,0.0003804896,0.01736473,0.002583993,0.00005514941,0.004077939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007221535,"threshold_uncertainty_score":0.02415848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06129955787227237,"score_gpt":0.3935979435547655,"score_spread":0.3322983856824931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}