{"id":"W2612164361","doi":"10.15406/ijcam.2017.06.00203","title":"Exploring Standardized Zembrin® Extracts from the South African plant Sceletium tortuosum in Dual Targeting Phosphodiesterase-4 (PDE-4) and Serotonin Reuptake Inhibition as potential treatment in Schizophrenia","year":2017,"lang":"en","type":"article","venue":"International Journal of Complementary & Alternative Medicine","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"","keywords":"Serotonin; Schizophrenia (object-oriented programming); Phosphodiesterase; Pharmacology; Reuptake; Medicine; Psychiatry; Chemistry; Psychology; Internal medicine; Biochemistry; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005542762,0.0002736256,0.0004866618,0.0001269905,0.0001557856,0.0001303768,0.000422083,0.0000318844,0.000844762],"category_scores_gemma":[0.0003359609,0.0001866268,0.00009431475,0.00003919133,0.0002073887,0.0004323439,0.0002061009,0.0003746414,0.000001795695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005119462,"about_ca_system_score_gemma":0.00007498098,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006895963,"about_ca_topic_score_gemma":0.0006790536,"domain_scores_codex":[0.9974963,0.00007453329,0.0009648238,0.0003018615,0.0008992777,0.0002632037],"domain_scores_gemma":[0.9981938,0.0003505214,0.0009241257,0.0002043106,0.0001953378,0.0001319333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01348988,0.0008874863,0.1782394,0.00004182656,0.001757764,0.008243213,0.0219211,0.0002207856,0.707987,0.0003948865,0.0005114694,0.06630524],"study_design_scores_gemma":[0.0427637,0.0007826234,0.1310011,0.00438502,0.0002463772,0.0004244714,0.02188293,0.0007822752,0.7772198,0.002696227,0.01702527,0.0007901821],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925726,0.0004604333,0.00004302886,0.005281873,0.0006412856,0.0001385291,0.0003915782,0.000007205051,0.0004634668],"genre_scores_gemma":[0.9966471,0.0006741766,0.0002987187,0.0001404873,0.002020979,0.00002325833,0.0001560074,0.00002011317,0.00001918197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06923292,"threshold_uncertainty_score":0.9997172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07169971962751756,"score_gpt":0.3034784598432738,"score_spread":0.2317787402157562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}