{"id":"W2612248406","doi":"10.1182/blood.v128.22.2923.2923","title":"Chromosome 9p24.1/PD-L1/PD-L2Alterations and PD-L1 Expression and Treatment Outcomes in Patients with Classical Hodgkin Lymphoma Treated with Nivolumab (PD-1 Blockade)","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Princess Margaret Cancer Centre","funders":"","keywords":"Brentuximab vedotin; Nivolumab; Medicine; Oncology; Internal medicine; Chlorambucil; Blockade; Polysomy; Cohort; Autologous stem-cell transplantation; Reed–Sternberg cell; PD-L1; Transplantation; Lymphoma; Cancer research; Chemotherapy; CD30; Receptor; Cyclophosphamide; Hodgkin lymphoma; Cancer; Biology; Immunotherapy; Chromosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002712462,0.0001669524,0.0002666326,0.0003821176,0.0002766056,0.0005130632,0.0001962283,0.0003422068,0.0008750131],"category_scores_gemma":[0.0005007631,0.0001451894,0.0002814354,0.0003558435,0.0002134554,0.0003436192,0.0002186163,0.000512423,0.0001676412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004269563,"about_ca_system_score_gemma":0.0001339851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008814771,"about_ca_topic_score_gemma":0.001361248,"domain_scores_codex":[0.9998417,0.00003336196,0.00001311397,0.00004644071,0.00002736555,0.00003797664],"domain_scores_gemma":[0.999676,0.00005098575,0.000132003,0.00001358587,0.0000264611,0.000100999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00472801,0.0003920164,0.98277,0.00002397169,0.0001734429,0.000196,0.00008498248,0.0002480008,0.003262731,0.00002919242,0.0003259256,0.007765824],"study_design_scores_gemma":[0.0001584167,0.001836835,0.9954791,0.00001037389,0.0001306552,0.0004706042,0.0001121249,0.0006756911,0.0005041066,0.00006275485,0.000550715,0.000008475906],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993722,0.0002555863,0.00002651984,0.00002551994,0.000003872843,0.000005852521,0.0001159602,0.000003035183,0.0001913928],"genre_scores_gemma":[0.9996063,0.00004751311,0.00002452763,0.00002284274,0.000006176366,0.000006615242,0.0001778422,8.490831e-7,0.0001074038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008814771,"threshold_uncertainty_score":0.003097832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007392563174687249,"score_gpt":0.2152760438936839,"score_spread":0.2078834807189966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}