{"id":"W2612699275","doi":"10.1186/s13058-017-0847-0","title":"Pathomimetic avatars reveal divergent roles of microenvironment in invasive transition of ductal carcinoma in situ","year":2017,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; Wayne State University; National Institutes of Health; National Cancer Institute; Barbara Ann Karmanos Cancer Institute","keywords":"Urokinase receptor; Ductal carcinoma; Cancer research; Tumor microenvironment; Cancer-Associated Fibroblasts; Stromal cell; Tumor progression; Stroma; Breast cancer; Plasminogen activator; Epithelial–mesenchymal transition; Myoepithelial cell; Biology; Extracellular matrix; Cancer; Medicine; Metastasis; Internal medicine; Immunology; Cell biology; Tumor cells; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001107555,0.0002944253,0.0001578083,0.0002072,0.00009366833,0.0002146527,0.0001443683,0.0002936253,0.001631545],"category_scores_gemma":[0.0001179159,0.0001339278,0.0002011996,0.00008333608,0.0001553717,0.000233189,0.0001920589,0.0006309174,0.0003187541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002037158,"about_ca_system_score_gemma":0.0001263433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001623092,"about_ca_topic_score_gemma":0.0002399418,"domain_scores_codex":[0.9998966,0.0000134894,0.000006777426,0.00002613575,0.00003062291,0.0000262735],"domain_scores_gemma":[0.9998881,0.00003306254,0.00003597657,0.000007751787,0.000008554627,0.00002651102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001139015,0.00003958545,0.0001554096,0.00002700178,0.000003335319,0.00003572337,0.00001082666,0.0002073061,0.9980201,0.0001353278,0.00002455498,0.001227011],"study_design_scores_gemma":[0.00003201689,0.0008812562,0.002458405,0.000007250837,0.00001892686,0.0003858188,0.00004369238,0.001566849,0.9907948,0.0001323546,0.003673066,0.000005644966],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929676,0.00110857,0.00392229,0.00009242137,0.00003700363,0.00004127589,0.000326481,0.00007282504,0.001431512],"genre_scores_gemma":[0.9907156,0.0008121468,0.005490653,0.00005954264,0.000009549899,0.00008518651,0.0005005849,0.00003473483,0.002292008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001631545,"threshold_uncertainty_score":0.005458117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04993475125090997,"score_gpt":0.3435383765475099,"score_spread":0.2936036252965999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}