{"id":"W2612699275","doi":"10.1186/s13058-017-0847-0","title":"Pathomimetic avatars reveal divergent roles of microenvironment in invasive transition of ductal carcinoma in situ","year":2017,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; Wayne State University; National Institutes of Health; National Cancer Institute; Barbara Ann Karmanos Cancer Institute","keywords":"Urokinase receptor; Ductal carcinoma; Cancer research; Tumor microenvironment; Cancer-Associated Fibroblasts; Stromal cell; Tumor progression; Stroma; Breast cancer; Plasminogen activator; Epithelial–mesenchymal transition; Myoepithelial cell; Biology; Extracellular matrix; Cancer; Medicine; Metastasis; Internal medicine; Immunology; Cell biology; Tumor cells; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000713515,0.0001067621,0.0003803311,0.0002953772,0.00005587471,0.000008783472,0.0001932346,0.00007755713,0.0003310469],"category_scores_gemma":[0.00003774599,0.00009927648,0.00008508169,0.0001492554,0.0003316328,0.00006605165,0.0001237117,0.0003495012,0.000004657787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003923512,"about_ca_system_score_gemma":0.0003755845,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0169239,"about_ca_topic_score_gemma":0.008797717,"domain_scores_codex":[0.9983215,0.0001289521,0.0003407751,0.000291349,0.0005730512,0.0003443709],"domain_scores_gemma":[0.9991789,0.00003739156,0.0001084026,0.0004623416,0.0001018889,0.0001110009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001837822,0.0004003427,0.2508233,0.000643608,0.00003565978,0.0002652264,0.002108995,0.00004677154,0.7205939,0.00001200773,0.0002628764,0.02296944],"study_design_scores_gemma":[0.002201904,0.0001342461,0.7536668,0.0005235701,0.00002401829,0.00003906824,0.0006296649,0.000005775456,0.2426394,0.00002456273,0.00004765102,0.0000633767],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949085,0.001510722,0.00000176158,0.00236452,0.00005246216,0.0005170763,0.0002428165,0.00000171592,0.0004004746],"genre_scores_gemma":[0.9978912,0.001782401,0.00006330815,0.00002930878,0.0000664145,0.0000704772,0.0000150875,0.00001529545,0.00006651129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5028434,"threshold_uncertainty_score":0.9896225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04993475125090997,"score_gpt":0.3435383765475099,"score_spread":0.2936036252965999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}