{"id":"W2612733314","doi":"10.1002/eji.201646795","title":"Regulation of immune cell signaling by SHIP1: A phosphatase, scaffold protein, and potential therapeutic target","year":2017,"lang":"en","type":"review","venue":"European Journal of Immunology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Institute of Infection and Immunity; Canadian Institutes of Health Research","keywords":"Biology; Immune system; Cell biology; Scaffold; Phosphatase; Scaffold protein; Signal transduction; Cell; Immunology; Biochemistry; Phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001236571,0.0003653002,0.001140204,0.0001692837,0.00007605037,0.00004043757,0.0007713326,0.0001931576,0.00002165965],"category_scores_gemma":[0.0001401111,0.0003127337,0.0003516769,0.00007044803,0.0002596542,0.00001677141,0.0002827615,0.0003909656,0.000005455487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002251067,"about_ca_system_score_gemma":0.0001938238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005922113,"about_ca_topic_score_gemma":2.633563e-7,"domain_scores_codex":[0.9970022,0.0009466957,0.0013156,0.000310336,0.0001467195,0.000278429],"domain_scores_gemma":[0.9963934,0.00002087285,0.002819722,0.0005676823,0.0001447878,0.00005352292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004169018,0.0002103314,0.000008747053,0.002473503,0.0006474529,0.000167758,0.00002318151,0.000009994787,0.316417,0.00009364151,0.0004476747,0.6790838],"study_design_scores_gemma":[0.001507988,0.001348209,0.0001117884,0.004218232,0.0003257036,0.0004277022,0.00001154273,8.562466e-7,0.270942,0.00005169184,0.7206463,0.0004080113],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007985248,0.9978951,0.0004846136,0.00001909202,0.0001881669,0.0004254257,0.0001098548,0.00000301877,0.00007619611],"genre_scores_gemma":[0.04961742,0.948832,0.0008702167,0.00001052706,0.0001454262,0.000006360761,0.000283383,0.0000801841,0.0001544797],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7201986,"threshold_uncertainty_score":0.9999325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02068935066640992,"score_gpt":0.2636312890490392,"score_spread":0.2429419383826293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}