{"id":"W2612761910","doi":"10.1161/circulationaha.112.111591","title":"High Levels of Circulating Epinephrine Trigger Apical Cardiodepression in a β <sub>2</sub> -Adrenergic Receptor/G <sub>i</sub> –Dependent Manner","year":2012,"lang":"en","type":"article","venue":"Circulation","topic":"Takotsubo Cardiomyopathy and Associated Phenomena","field":"Medicine","cited_by":754,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia Hospital","funders":"Biotechnology and Biological Sciences Research Council; British Heart Foundation; Wellcome Trust","keywords":"Medicine; Epinephrine; Adrenergic receptor; Internal medicine; Adrenergic; Endocrinology; Receptor; β2 adrenergic receptor; Agonist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001001297,0.0003589026,0.0008892159,0.0003931196,0.0001102147,0.00002160707,0.0001091841,0.0003899519,0.00004671172],"category_scores_gemma":[0.0002780829,0.0003518712,0.0003505564,0.0006799229,0.00006392685,0.0003897948,0.00008704636,0.0004666008,0.00007521223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004519705,"about_ca_system_score_gemma":0.00009103294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003051695,"about_ca_topic_score_gemma":0.000003430443,"domain_scores_codex":[0.9967762,0.0003124154,0.0009246178,0.0005027329,0.0008074908,0.0006766007],"domain_scores_gemma":[0.998449,0.0001393448,0.0004292636,0.000506531,0.0002006568,0.0002752534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000129964,0.0002529545,0.1292299,0.0001466145,0.0001403652,0.00001980527,0.0005704859,0.004422493,0.8313684,0.0002342314,0.00006347888,0.03342137],"study_design_scores_gemma":[0.002538113,0.00004255835,0.6854794,0.0003376161,0.0001750226,0.00004155393,0.00007932445,0.0005644624,0.3102134,0.0001835895,0.00005045601,0.0002944903],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955922,0.001223388,0.001008025,0.0001137311,0.000684893,0.0006364246,0.00005163356,0.0001111197,0.0005786029],"genre_scores_gemma":[0.9983231,0.00007932121,0.0001218658,0.00007912494,0.0009851631,0.00006433774,0.0002660856,0.00007163164,0.000009409399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5562496,"threshold_uncertainty_score":0.9998933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02051236821514792,"score_gpt":0.2430563438317009,"score_spread":0.2225439756165529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}