{"id":"W2612761910","doi":"10.1161/circulationaha.112.111591","title":"High Levels of Circulating Epinephrine Trigger Apical Cardiodepression in a β <sub>2</sub> -Adrenergic Receptor/G <sub>i</sub> –Dependent Manner","year":2012,"lang":"en","type":"article","venue":"Circulation","topic":"Takotsubo Cardiomyopathy and Associated Phenomena","field":"Medicine","cited_by":754,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia Hospital","funders":"Biotechnology and Biological Sciences Research Council; British Heart Foundation; Wellcome Trust","keywords":"Medicine; Epinephrine; Adrenergic receptor; Internal medicine; Adrenergic; Endocrinology; Receptor; β2 adrenergic receptor; Agonist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008989561,0.0003657,0.0002355716,0.0001064105,0.00009317535,0.0002228821,0.0001518645,0.0002360962,0.001241643],"category_scores_gemma":[0.00009842614,0.0001288163,0.0002460231,0.00005907037,0.0002873599,0.0001827271,0.0001648822,0.0005941265,0.000252988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001663884,"about_ca_system_score_gemma":0.0001108416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001683377,"about_ca_topic_score_gemma":0.0003855064,"domain_scores_codex":[0.9999048,0.00001541401,0.00000767394,0.00001816864,0.00002037945,0.00003368956],"domain_scores_gemma":[0.9999014,0.00001369096,0.00003610488,0.00001327944,0.000006363603,0.00002914277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006385426,0.00009335743,0.0007931058,0.00004713615,0.000008841075,0.0003847944,0.00002395834,0.00003414846,0.9963244,0.0001136843,0.00009193637,0.001446252],"study_design_scores_gemma":[0.0001751635,0.006815626,0.09584463,0.00004783819,0.0001268808,0.002643971,0.0002324695,0.001921751,0.8886817,0.0003291574,0.003157797,0.00002311925],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949655,0.001366811,0.001623323,0.0001145323,0.00008960398,0.00003633964,0.0001466348,0.00005248136,0.001604814],"genre_scores_gemma":[0.9971681,0.000847482,0.0008216812,0.0001154374,0.00004937177,0.00004487589,0.000157544,0.000006311299,0.0007892412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001241643,"threshold_uncertainty_score":0.004153728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02051236821514792,"score_gpt":0.2430563438317009,"score_spread":0.2225439756165529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}