{"id":"W2612820192","doi":"10.1021/acsami.7b03160","title":"Dipole Orientation Matters: Longer-Circulating Choline Phosphate than Phosphocholine Liposomes for Enhanced Tumor Targeting","year":2017,"lang":"en","type":"article","venue":"ACS Applied Materials & Interfaces","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Ministry of Education of the People's Republic of China; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Liposome; Phosphocholine; Membrane; Materials science; Biocompatibility; Biophysics; Choline; Ethylene glycol; Lipid bilayer; Drug delivery; Phosphatidylcholine; Chemistry; Nanotechnology; Phospholipid; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002134412,0.0003676402,0.0001483214,0.0001477038,0.000103224,0.0003799278,0.0001826356,0.0003850433,0.001358752],"category_scores_gemma":[0.000240672,0.0001232368,0.000142182,0.0001473467,0.0001917101,0.0004104467,0.0003483896,0.0004245439,0.0005243981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002605012,"about_ca_system_score_gemma":0.0002583464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004342065,"about_ca_topic_score_gemma":0.0004566137,"domain_scores_codex":[0.9999075,0.00001392019,0.000007230674,0.00002182011,0.00002538519,0.0000240529],"domain_scores_gemma":[0.9998877,0.00001877415,0.00003498846,0.00000978093,0.00002273083,0.00002597366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004906925,0.00001062999,0.0000555212,0.00003057296,0.000001945513,0.00002323183,0.000009349843,0.00007136458,0.9975098,0.0001814015,0.00004888364,0.00200815],"study_design_scores_gemma":[0.00001325206,0.00007320147,0.0003315629,0.000002190423,0.000007297803,0.00005868865,0.000006070696,0.0008314796,0.9973181,0.00004358805,0.001310853,0.000003783701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808379,0.002575493,0.01175951,0.0005615649,0.00008832141,0.00008661734,0.000176276,0.0001662348,0.003748098],"genre_scores_gemma":[0.9926243,0.0009204692,0.00416276,0.0001339638,0.00001919178,0.00002793693,0.00008714498,0.00003352198,0.001990716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001358752,"threshold_uncertainty_score":0.00454545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01076616157910286,"score_gpt":0.2890002864558697,"score_spread":0.2782341248767669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}