{"id":"W2612952098","doi":"10.3390/v9050107","title":"A Conserved Residue, Tyrosine (Y) 84, in H5N1 Influenza A Virus NS1 Regulates IFN Signaling Responses to Enhance Viral Infection","year":2017,"lang":"en","type":"article","venue":"Viruses","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Toronto General Hospital; University of Toronto; Canada Research Chairs; University Health Network","funders":"","keywords":"Biology; Interferon; Virology; Influenza A virus; Virulence; Tyrosine; Virus; Downregulation and upregulation; Tyrosine phosphorylation; Titer; Influenza A virus subtype H5N1; Phosphorylation; Recombinant DNA; Gene; Cell biology; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006112226,0.0003195332,0.0004661744,0.0004417745,0.0006239013,0.0001669893,0.0004661493,0.0003244216,0.0005064045],"category_scores_gemma":[0.002153338,0.0003000854,0.0001132142,0.0001427693,0.0003702303,0.0004582437,0.0002861927,0.0003847458,0.001397287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009232785,"about_ca_system_score_gemma":0.0001389795,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007834419,"about_ca_topic_score_gemma":0.002508942,"domain_scores_codex":[0.9977404,0.0005868152,0.0005671108,0.0004828386,0.00006016478,0.0005626054],"domain_scores_gemma":[0.9982991,0.0004201944,0.0002790724,0.0008457395,0.0001139032,0.00004203973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008099965,0.0001351266,0.02111609,0.0000188423,0.00007809266,0.00002102457,0.0004524883,0.00001103465,0.9660822,0.0001766748,0.001974714,0.00183371],"study_design_scores_gemma":[0.0008534984,0.0004632571,0.1622954,0.0002865739,0.00001881788,0.00002460417,0.00004150646,0.000001409031,0.7900159,0.00009036881,0.04562001,0.000288596],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953361,0.002663206,0.00003847615,0.0003029567,0.0006961898,0.0003676543,0.00005161309,0.0001406066,0.000403168],"genre_scores_gemma":[0.9937165,0.0001491619,0.00009481204,0.00193048,0.00005100767,0.00007390458,0.000009037578,0.00003781915,0.003937218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1760663,"threshold_uncertainty_score":0.9999451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03726618610878633,"score_gpt":0.3406353794157945,"score_spread":0.3033691933070081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}