{"id":"W2612952098","doi":"10.3390/v9050107","title":"A Conserved Residue, Tyrosine (Y) 84, in H5N1 Influenza A Virus NS1 Regulates IFN Signaling Responses to Enhance Viral Infection","year":2017,"lang":"en","type":"article","venue":"Viruses","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Toronto General Hospital; University of Toronto; Canada Research Chairs; University Health Network","funders":"","keywords":"Biology; Interferon; Virology; Influenza A virus; Virulence; Tyrosine; Virus; Downregulation and upregulation; Tyrosine phosphorylation; Titer; Influenza A virus subtype H5N1; Phosphorylation; Recombinant DNA; Gene; Cell biology; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005399862,0.0001700508,0.0001074143,0.00005963524,0.0001206212,0.000128325,0.0001008668,0.0001069141,0.00056371],"category_scores_gemma":[0.00003541284,0.00004968169,0.0001171392,0.00004926162,0.0001248295,0.00009557856,0.0001029761,0.0002172822,0.0002416197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000291959,"about_ca_system_score_gemma":0.0001539367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001191024,"about_ca_topic_score_gemma":0.001363055,"domain_scores_codex":[0.9999669,0.000005007024,0.000002682307,0.000007547262,0.000006902975,0.00001089177],"domain_scores_gemma":[0.9999712,0.000002656996,0.00001095364,0.00000267923,0.000003365732,0.000009206081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001283541,0.00001242174,0.0005980611,0.0000176091,0.000002362387,0.0000530817,0.000008278143,0.00006395631,0.9983813,0.00002964136,0.00002128918,0.0006837241],"study_design_scores_gemma":[0.00002620349,0.0003464825,0.03628593,0.000008911539,0.00001717559,0.0003636671,0.00007369654,0.001316651,0.9590052,0.00005858256,0.002491442,0.000006117502],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986385,0.0004449044,0.0003916938,0.00002614561,0.000008947395,0.000005882592,0.00009817672,0.00001065222,0.0003751687],"genre_scores_gemma":[0.9981749,0.0003478857,0.0003917841,0.00001644406,0.00000296831,0.000005416286,0.0001680232,0.000003830648,0.0008886739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001191024,"threshold_uncertainty_score":0.002368152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03726618610878633,"score_gpt":0.3406353794157945,"score_spread":0.3033691933070081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}