{"id":"W2612965864","doi":"10.1166/msr.2016.1050","title":"Carvedilol Inhibits cADPR- and IP<sub>3</sub>-Induced Ca<sup>2</sup><sup>+</sup> Release","year":2016,"lang":"en","type":"article","venue":"Messenger","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Wellcome Trust","keywords":"Carvedilol; Ryanodine receptor; Chemistry; Endoplasmic reticulum; Sea urchin; Caffeine; Antagonist; Mechanism of action; Biophysics; Inositol; Pharmacology; Internal medicine; Receptor; Biochemistry; Heart failure; Biology; Cell biology; In vitro; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001358125,0.0003327664,0.0004382252,0.0002919072,0.0002024508,0.0005250386,0.0005471618,0.0004457401,0.004478246],"category_scores_gemma":[0.0004802974,0.0001800409,0.0003083737,0.0002047715,0.0007035991,0.0004222445,0.0003228164,0.001221959,0.001321257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004863926,"about_ca_system_score_gemma":0.0005977876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001591884,"about_ca_topic_score_gemma":0.002314566,"domain_scores_codex":[0.9998413,0.00002076204,0.000009386105,0.00001080681,0.00003105473,0.00008659573],"domain_scores_gemma":[0.9998179,0.00006531613,0.00002885572,0.00002453198,0.00002038478,0.00004305078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004237738,0.0003619347,0.0006019933,0.0004013725,0.00004458767,0.0006468036,0.0001430202,0.0001930083,0.9726583,0.001372226,0.00134846,0.01799053],"study_design_scores_gemma":[0.0006634081,0.001812852,0.01510829,0.00003531459,0.00008920675,0.001239807,0.0002249705,0.002480158,0.9688292,0.000644693,0.008845225,0.00002705759],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.978143,0.00534304,0.002946376,0.0008822018,0.0001359465,0.000103264,0.001024259,0.0005444101,0.01087747],"genre_scores_gemma":[0.9898148,0.003295181,0.001212564,0.0002679612,0.0000698766,0.00005411698,0.0008252015,0.00004998887,0.004410255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004478246,"threshold_uncertainty_score":0.01498121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01039355488050413,"score_gpt":0.2250922513432477,"score_spread":0.2146986964627436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}