{"id":"W2613022045","doi":"10.1176/appi.ajp.2017.16121402","title":"Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa","year":2017,"lang":"en","type":"review","venue":"American Journal of Psychiatry","topic":"Eating Disorders and Behaviors","field":"Psychology","cited_by":600,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Human Genome Research Institute; National Institute on Alcohol Abuse and Alcoholism; Instituto de Salud Carlos III; Korea Centers for Disease Control and Prevention; National Health and Medical Research Council; Menzies Centre for Australian Studies, King's College London, University of London; Medical Research Council; Canadian Institutes of Health Research; School of Medicine, University of North Carolina at Chapel Hill; National Institutes of Health; Regione del Veneto; Institut National de la Recherche Agronomique; Horizon 2020 Framework Programme; Vetenskapsrådet; Genesis Pharma; University of Toronto; Generalitat de Catalunya; China Scholarship Council; Ministerio de Economía y Competitividad; Bundesministerium für Bildung und Forschung; Bergens Forskningsstiftelse; Louis and Harold Price Foundation; Universitetet i Bergen; National Institute of Mental Health; Eesti Teadusagentuur; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Flinders University; Government of Ontario; Institut National de la Santé et de la Recherche Médicale; Ministerstvo Zdravotnictví Ceské Republiky; AstraZeneca; EkstraStiftelsen Helse og Rehabilitering (Stiftelsen Dam); European Commission; ZonMw; University of Cambridge; Broad Institute; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Sanofi; South London and Maudsley NHS Foundation Trust; Bristol-Myers Squibb; Wellcome Trust; Lundbeckfonden; Eli Lilly and Company; Genome Canada; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; NHS Blood and Transplant; University of Otago; University of California; H. Lundbeck A/S; Klarman Family Foundation; Norges Forskningsråd; Schweizerische Anorexia Nervosa Stiftung; Alexander von Humboldt-Stiftung; Aarhus Universitet; Massachusetts General Hospital; GlaxoSmithKline; Pfizer; European Regional Development Fund; King's College London; Children's Hospital of Philadelphia; Centers for Disease Control and Prevention; National Alliance for Research on Schizophrenia and Depression; National and Kapodistrian University of Athens; Karolinska Institutet","keywords":"Anorexia nervosa; Genome-wide association study; Locus (genetics); Association (psychology); Genetics; Genetic association; Psychology; Biology; Clinical psychology; Single-nucleotide polymorphism; Eating disorders; Genotype; Gene; Psychotherapist","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001275948,0.0007751683,0.001679288,0.002967566,0.0001985453,0.0007523212,0.000792728,0.0008994293,0.00142928],"category_scores_gemma":[0.001397397,0.0002990744,0.0005847691,0.002383902,0.0004936822,0.000617383,0.0005511511,0.001094465,0.000593058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004201575,"about_ca_system_score_gemma":0.001319805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001794514,"about_ca_topic_score_gemma":0.00271109,"domain_scores_codex":[0.9996549,0.00008656836,0.00007122006,0.00006897502,0.00009771032,0.00002055277],"domain_scores_gemma":[0.9993303,0.0003285122,0.0001242772,0.00001372565,0.0001486222,0.00005456391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0001388974,0.00004803275,0.002943922,0.01764507,0.0004964697,0.000501578,0.0000767947,0.0002101282,0.0006441253,0.001200625,0.01537001,0.9607244],"study_design_scores_gemma":[0.0001897089,0.0004921877,0.06484912,0.02767292,0.003295206,0.01411447,0.0005042762,0.000550435,0.001221771,0.004570636,0.8823688,0.0001705071],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001837394,0.9992267,0.00006787469,0.0002194485,0.00007984592,0.000003474493,0.00001122271,0.000003303807,0.000204467],"genre_scores_gemma":[0.001163383,0.9983375,0.0001596996,0.00009301977,0.0001207036,0.000006212556,0.00002053583,9.333817e-7,0.00009805451],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002967566,"threshold_uncertainty_score":0.006747901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03478487975018748,"score_gpt":0.3614247237246569,"score_spread":0.3266398439744695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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