{"id":"W2613024169","doi":"10.1161/res.111.suppl_1.a177","title":"Abstract 177: Overexpression of Cardiac Troponin I-Interacting Kinase, a Cardiac-Specific MAPKKK, Promotes Cardiac Dysfunction","year":2012,"lang":"en","type":"article","venue":"Circulation Research","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas College","funders":"","keywords":"ASK1; Cyclin-dependent kinase 9; MAP kinase kinase kinase; Protein kinase A; Protein kinase R; Mitogen-activated protein kinase kinase; Cardiomyopathy; Cyclin-dependent kinase 2; Kinase; Cyclin-dependent kinase 4; Cardiac function curve; Biology; Cancer research; Medicine; Cell biology; Internal medicine; Heart failure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009716904,0.0004625683,0.0001970243,0.0001996025,0.0002000739,0.0001944681,0.0001948752,0.0002447202,0.005133829],"category_scores_gemma":[0.00009040945,0.0001075237,0.0001955048,0.0001528002,0.0002480061,0.0001930835,0.0001582455,0.0004293435,0.00145381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003882704,"about_ca_system_score_gemma":0.000255802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002818212,"about_ca_topic_score_gemma":0.0003108365,"domain_scores_codex":[0.9999411,0.000006237186,0.000008137555,0.00001333089,0.00001866875,0.00001252984],"domain_scores_gemma":[0.999956,0.000005377753,0.00001200782,0.000003701621,0.000005068503,0.00001775709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002062376,0.00003390392,0.0001575546,0.00006700044,0.00000485325,0.0001114601,0.000006766869,0.00002168018,0.9970033,0.0001907566,0.0002750226,0.001921488],"study_design_scores_gemma":[0.0000830076,0.0003916384,0.00671264,0.00001418194,0.00002914391,0.0009774349,0.00001926688,0.0003808897,0.9817525,0.0001634904,0.009470575,0.000005341277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9791536,0.005634988,0.004057428,0.0007212602,0.0003623875,0.00006335856,0.001644847,0.0002312976,0.008130689],"genre_scores_gemma":[0.9692012,0.004574483,0.004899382,0.0002778406,0.0001257021,0.00008565404,0.002868802,0.00008505291,0.01788192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005133829,"threshold_uncertainty_score":0.01717442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09042223317588903,"score_gpt":0.370212612578284,"score_spread":0.2797903794023949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}