{"id":"W2613032309","doi":"10.18632/oncotarget.17848","title":"Prolonged mitotic arrest induced by Wee1 inhibition sensitizes breast cancer cells to paclitaxel","year":2017,"lang":"en","type":"article","venue":"Oncotarget","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates; Cancer Research Society","keywords":"Wee1; Mitosis; Mitotic catastrophe; Cell cycle; Cancer research; Cancer; Cancer cell; Breast cancer; Cyclin B1; Medicine; Cell cycle checkpoint; Cyclin-dependent kinase 1; Biology; Internal medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001141005,0.0002009183,0.0001810445,0.00002744829,0.0002603086,0.00009601643,0.0002000037,0.0002086639,0.00002766931],"category_scores_gemma":[0.00003305525,0.0001968235,0.00008291127,0.00003045278,0.0000549391,0.000009374139,0.000155987,0.00011956,0.00005482648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003460064,"about_ca_system_score_gemma":0.00008113097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000358382,"about_ca_topic_score_gemma":0.0004702302,"domain_scores_codex":[0.9989015,0.00004211077,0.0001762333,0.0004298802,0.0001179886,0.0003323164],"domain_scores_gemma":[0.9989907,0.000004850638,0.0001299287,0.0006098574,0.00009944566,0.0001652658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007995521,0.00007306673,0.004122887,0.00001628226,0.00003672285,0.000004929212,0.00004214523,0.00000837157,0.9548621,0.000005725673,0.04012476,0.0006230724],"study_design_scores_gemma":[0.0006812245,0.0001668751,0.02472487,0.0000514522,0.00002981326,0.00001021635,0.00003388705,0.00003021891,0.9476984,0.00002270573,0.02618358,0.0003667402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957735,0.0001446121,0.0001391189,0.002146304,0.0005815232,0.0003107886,0.000362155,0.00001650349,0.0005254752],"genre_scores_gemma":[0.9966431,0.000136518,0.0003201675,0.001050743,0.0006130064,0.0000527646,0.0001790626,0.00003586057,0.0009687307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02060199,"threshold_uncertainty_score":0.802623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008203292158750302,"score_gpt":0.2555583349889867,"score_spread":0.2473550428302364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}