{"id":"W2613292714","doi":"10.1038/ncomms15244","title":"HLA-DP84Gly constitutively presents endogenous peptides generated by the class I antigen processing pathway","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; National Institutes of Health","keywords":"Transporter associated with antigen processing; Antigen processing; CD74; Antigen presentation; MHC class I; Endoplasmic reticulum; Cell biology; Endogeny; Antigen; Biology; MHC class II; Endosome; Peptide; Human leukocyte antigen; Intracellular; Major histocompatibility complex; Chemistry; Biochemistry; Genetics; Cytotoxic T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007979672,0.0002315126,0.0001043539,0.00006766473,0.00007329146,0.0002817554,0.0001228921,0.0001666467,0.001440485],"category_scores_gemma":[0.00009455949,0.00009472402,0.00009022212,0.00007042263,0.0001587412,0.0001538171,0.000184563,0.0004162841,0.0003392683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001157888,"about_ca_system_score_gemma":0.00006895869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001372042,"about_ca_topic_score_gemma":0.0001260267,"domain_scores_codex":[0.9998944,0.00002951045,0.000008035505,0.00002774113,0.00001753856,0.00002284037],"domain_scores_gemma":[0.9999228,0.00001689508,0.00002062092,0.0000134948,0.000004800914,0.00002146519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000534029,0.000007838403,0.0004547082,0.00000963651,0.000002542908,0.0000685763,0.000006313663,0.00001287674,0.9988934,0.00006445035,0.00001616307,0.0004102729],"study_design_scores_gemma":[0.00002567554,0.0006059803,0.01081038,0.000007479265,0.00002352787,0.003237424,0.0001001686,0.0007465782,0.9802536,0.0001667723,0.004016027,0.000006509238],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979779,0.0002155825,0.0009250935,0.00002248174,0.00001523393,0.000004669304,0.00007645407,0.00001610978,0.0007463627],"genre_scores_gemma":[0.9982752,0.0001446413,0.0008357529,0.00002665062,0.000007832176,0.000005050553,0.0001169211,0.0000063987,0.0005816207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001440485,"threshold_uncertainty_score":0.004818916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04425989920730006,"score_gpt":0.3016200676844149,"score_spread":0.2573601684771148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}