{"id":"W2613292714","doi":"10.1038/ncomms15244","title":"HLA-DP84Gly constitutively presents endogenous peptides generated by the class I antigen processing pathway","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; National Institutes of Health","keywords":"Transporter associated with antigen processing; Antigen processing; CD74; Antigen presentation; MHC class I; Endoplasmic reticulum; Cell biology; Endogeny; Antigen; Biology; MHC class II; Endosome; Peptide; Human leukocyte antigen; Intracellular; Major histocompatibility complex; Chemistry; Biochemistry; Genetics; Cytotoxic T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.0004256053,0.0002424656,0.0002589363,0.00006297672,0.006026332,0.0002463489,0.003492939,0.0005412809,0.00006004443],"category_scores_gemma":[0.0004819189,0.0001735818,0.0001162848,0.0001122647,0.002003324,0.0003006867,0.0005861472,0.001474072,0.000176588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004630997,"about_ca_system_score_gemma":0.0003017316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002325817,"about_ca_topic_score_gemma":0.0001282374,"domain_scores_codex":[0.9983202,0.0006480022,0.0003169217,0.0002609328,0.00006393835,0.0003899833],"domain_scores_gemma":[0.9958404,0.0003651866,0.0003875245,0.003112289,0.0002747832,0.00001981583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001719213,0.0002703516,0.003497624,0.000005632629,0.0003280012,0.000002172523,0.0007734499,0.00000138601,0.9540275,0.003307852,0.01287761,0.02473652],"study_design_scores_gemma":[0.0007218634,0.00004339004,0.006551788,0.00004104666,0.00002944369,0.0001059478,0.0002338882,0.00002226302,0.2464447,0.00005870453,0.7455435,0.0002034425],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.418859,0.5112506,0.0001005163,0.01075627,0.00119976,0.001290259,0.000538494,0.0002898725,0.05571528],"genre_scores_gemma":[0.9908926,0.003728602,0.0001659772,0.0004388115,0.00002526512,0.00008712208,0.0003290849,0.00002630754,0.004306222],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7326659,"threshold_uncertainty_score":0.9952677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04425989920730006,"score_gpt":0.3016200676844149,"score_spread":0.2573601684771148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}