{"id":"W2613581156","doi":"10.1002/1878-0261.12076","title":"Dovitinib enhances temozolomide efficacy in glioblastoma cells","year":2017,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Leona M. and Harry B. Helmsley Charitable Trust; Ipsen; Cancer Research Society; Research Manitoba; National Cancer Institute; National Institutes of Health","keywords":"Temozolomide; LIN28; Cancer research; Viability assay; DNA damage; DNA repair; Stem cell; Biology; Cell; Chemistry; Medicine; Cell biology; Glioma; Induced pluripotent stem cell; DNA; Biochemistry; Embryonic stem cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008262762,0.0002234577,0.0004381291,0.0001735455,0.0001127167,0.0003393217,0.0001775436,0.0002095642,0.0008367379],"category_scores_gemma":[0.00007466736,0.0001022639,0.0001740748,0.0001598808,0.0001013285,0.0001466543,0.0001360239,0.0004810761,0.0002394071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000267217,"about_ca_system_score_gemma":0.0002360055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001497139,"about_ca_topic_score_gemma":0.002812365,"domain_scores_codex":[0.999922,0.00001135155,0.000008092521,0.00000998911,0.00001962667,0.00002880038],"domain_scores_gemma":[0.9999716,0.000003918158,0.000005214546,0.000003769669,0.000004794226,0.00001068714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001277157,0.0004532653,0.0006134969,0.0001184509,0.00002410988,0.00007051393,0.00004974094,0.0003128212,0.9844578,0.0001861713,0.0006862984,0.01175032],"study_design_scores_gemma":[0.0002331952,0.003549982,0.01501345,0.00001250971,0.00005605104,0.0002795414,0.00005914594,0.00298983,0.9717318,0.00005947366,0.006003429,0.00001150465],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965783,0.0009854492,0.0003144084,0.00009668787,0.00004725299,0.00002069959,0.0002774401,0.0000640382,0.0016157],"genre_scores_gemma":[0.9971595,0.0005915207,0.000330145,0.00004981412,0.000008092868,0.0000212581,0.0004720255,0.000007921602,0.001359712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001497139,"threshold_uncertainty_score":0.002976894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01538079668260446,"score_gpt":0.3279723765970851,"score_spread":0.3125915799144807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}